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  4. Recombinant Streptokinase A (ska)

Recombinant Streptokinase A (ska)

  • 货号：
    CSB-YP318760SMT
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP318760SMT
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP318760SMT-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP318760SMT
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP318760SMT
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ska
  • Uniprot No.：
  • 别名：
    ska; SPy_1979; M5005_Spy1684Streptokinase A
  • 种属：
    Streptococcus pyogenes serotype M1
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-440
  • 氨基酸序列
    IAGY GWLPDRPPIN NSQLVVSMAG IVEGTDKKVF INFFEIDLTS QPAHGGKTEQ GLSPKSKPFA TDNGAMPHKL EKADLLKAIQ KQLIANVHSN DGYFEVIDFA SDATITDRNG KVYFADKDGS VTLPTQPVQE FLLKGHVRVR PYKEKPVQNQ AKSVDVEYTV QFTPLNPDDD FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKTHPGY TIYERDSSIV THDNDIFRTI LPMDQEFTYH VKNREQAYEI NPKTGIKEKT NNTDLVSEKY YVLKQGEKPY DPFDRSHLKL FTIKYVDVNT NELLKSEQLL TASERNLDFR DLYDPRDKAK LLYNNLDAFD IMDYTLTGKV EDNHDKNNRV VTVYMGKRPK GAKGSYHLAY DKDLYTEEER KAYSYLRDTG TPIPDNPKDK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.
  • 基因功能参考文献：
    1. These studies demonstrate that GAS virulence can be explained by disparate hPg activation by SK2a and SK2b coupled with the coinherited M-proteins of these strains. PMID: 26070561
    2. Activation of contact system factors at the surface of the Streptococcus pyogenes serotype M49 is dependent on streptokinase. PMID: 25987706
    3. the recombinant E. coli BL21 DE3/pESK system could be potentially applied for large-scale production of streptokinase used in the therapy of acute myocardial infarction. PMID: 24883307
    4. Small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA. PMID: 21143309
  • 数据库链接：

    KEGG: spy:SPy_1979

    STRING: 160490.SPy_1979