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  4. Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

  • 中文名称：
    Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5(CLN5),Yeast
  • 货号：
    CSB-YP005567SH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5(CLN5),Yeast
  • 货号：
    CSB-EP005567SH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5(CLN5),Yeast
  • 货号：
    CSB-EP005567SH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5(CLN5),Yeast
  • 货号：
    CSB-BP005567SH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Sheep Ceroid-lipofuscinosis neuronal protein 5(CLN5),Yeast
  • 货号：
    CSB-MP005567SH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CLN5
  • Uniprot No.：
  • 别名：
    CLN5Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5; secreted form]
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    47-361
  • 氨基酸序列
    AGDP SRRQWPVPYK RFSFRPEPDP YCQAKYTFCP TGSPIPVMKD DDVIEVFRLQ APVWEFKYGD LLGHLKIMHD AIGFRSTLTE KNYTMEWYEL FQLGNCTFPH LRPEMNAPFW CNQGAACFFE GIDDNHWKEN GTLVLVATIS GGMFNKMAKW VKQDNETGIY YETWTVQASP KKEAEKWFES YDCSKFVLRT YEKLAELGAD FKKIETNYTR IFLYSGEPTY LGNETSVFGP TGNKTLALAI KKFYYPFKPH LSTKEFLLSL LQIFDAVVIH REFYLFYNFE YWFLPMKSPF IKITYEEIPL PNRKNRTLSG L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
  • 基因功能参考文献：
    1. We conclude that, whereas sleep homeostasis is present in CLN5(-/-) sheep, underlying CLN5(-/-) disease processes prevent its full expression, even at early stages. PMID: 27488642
    2. CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3 PMID: 17988881
  • 相关疾病：
    Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in New Zealand Borderdale sheep.
  • 亚细胞定位：
    [Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    CLN5 family
  • 数据库链接：

    KEGG: oas:100034668

    UniGene: Oar.7337