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  4. Recombinant Salmonella typhimurium NAD-dependent protein deacylase (cobB)

Recombinant Salmonella typhimurium NAD-dependent protein deacylase (cobB)

  • 中文名称：
    Recombinant Salmonella typhimurium NAD-dependent protein deacylase(cobB),Yeast
  • 货号：
    CSB-YP358218SXB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Salmonella typhimurium NAD-dependent protein deacylase(cobB),Yeast
  • 货号：
    CSB-EP358218SXB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Salmonella typhimurium NAD-dependent protein deacylase(cobB),Yeast
  • 货号：
    CSB-EP358218SXB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Salmonella typhimurium NAD-dependent protein deacylase(cobB),Yeast
  • 货号：
    CSB-BP358218SXB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Salmonella typhimurium NAD-dependent protein deacylase(cobB),Yeast
  • 货号：
    CSB-MP358218SXB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cobB
  • Uniprot No.：
  • 别名：
    cobB; STM1221; NAD-dependent protein deacylase; EC 2.3.1.286; Regulatory protein SIR2 homolog
  • 种属：
    Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-236
  • 氨基酸序列
    MENPRVLVLT GAGISAESGI RTFRAADGLW EEHRVEDVAT PEGFARNPGL VQTFYNARRQ QLQQPEIQPN AAHLALAKLE EALGDRFLLV TQNIDNLHER AGNRNIIHMH GELLKVRCSQ SGQILEWNGD VMPEDKCHCC QFPAPLRPHV VWFGEMPLGM DEIYMALSMA DIFIAIGTSG HVYPAAGFVH EAKLHGAHTV ELNLEPSQVG SEFEEKHYGP ASQVVPEFVD KFLKGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. Overexpression compensates for a cobT deletion, suggesting it may have N(1)-alpha-phosphoribosyltransferase activity; alternatively this protein may stimulate synthesis of an enzyme with the CobT activity.
  • 基因功能参考文献：
    1. findings show that the TacT toxin and the TacA antitoxin work as a complex that modulates TacT activity via the acetylation state of TacA; TacT acetylates TacA at residue K44, a modification that is removed by the NAD(+)-dependent CobB sirtuin deacetylase PMID: 28559487
    2. Data show that CobB, a known Sir2-like bacterial lysine deacetylase, catalyzes lysine dehomocysteinylation reactions both in vitro and in vivo. PMID: 27696686
    3. The enterobacterium Salmonella enterica synthesizes two isoforms of CobB sirtuin, a shorter 236-amino-acid isoform (here CobB(S)) and a longer 273-amino-acid isoform (here CobB(L)). PMID: 20889757
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Sirtuin family, Class III subfamily
  • 数据库链接：

    KEGG: stm:STM1221

    STRING: 99287.STM1221