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  4. Recombinant Saccharomyces cerevisiae AP-1-like transcription factor YAP5 (YAP5)

Recombinant Saccharomyces cerevisiae AP-1-like transcription factor YAP5 (YAP5)

  • 中文名称：
    酿酒酵母YAP5重组蛋白
  • 货号：
    CSB-YP340276SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母YAP5重组蛋白
  • 货号：
    CSB-EP340276SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母YAP5重组蛋白
  • 货号：
    CSB-EP340276SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母YAP5重组蛋白
  • 货号：
    CSB-BP340276SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母YAP5重组蛋白
  • 货号：
    CSB-MP340276SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YAP5
  • Uniprot No.：
  • 别名：
    YAP5; YIR018W; AP-1-like transcription factor YAP5
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-245
  • 氨基酸序列
    MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE DYETEENDEE LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY ETKLNRLQNE LQAKESENHA LKQKLETLTL KQASVPAQDP ILQNLIENFK PMKAIPIKYN TAIKRHQHST ELPSSVKCGF CNDNTTCVCK ELETDHRKSD DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI RSIIH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).
  • 基因功能参考文献：
    1. Fe/S cluster binding to Yap5-activator domain induces a conformational change that may activate transcription PMID: 25368382
    2. loss of activity of the cytosolic iron-sulfur cluster assembly complex proteins or deletion of cytosolic glutaredoxins did not reduce expression of Yap5 target genes PMID: 22915593
    3. we propose that under Fe-adequacy Yap5 is activated leading to the upregulation of CCC1 with the consequent accumulation of Fe in the vacuole and deprivation of the cytosolic iron pool. PMID: 22616008
    4. the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters PMID: 21917924
    5. These results show that Yap5 is an iron-sensing transcription factor and that iron regulates transcriptional activation. PMID: 18070921

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    BZIP family, YAP subfamily
  • 数据库链接：

    KEGG: sce:YIR018W

    STRING: 4932.YIR018W