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  4. Recombinant Rotavirus C Intermediate capsid protein VP6

Recombinant Rotavirus C Intermediate capsid protein VP6

  • 货号：
    CSB-YP300844RHJ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP300844RHJ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP300844RHJ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP300844RHJ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP300844RHJ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Intermediate capsid protein VP6
  • 种属：
    Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-395
  • 氨基酸序列
    MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG IGTQPQKEWN FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI VREASRNGMQ PQSPALILLS SSKFKTINFN NSSQSIKNWN AQSRRENPVY EYKNPMLFEY KNSYILQRAN PQFGSVMGLR YYTTSNTCQI AAFDSTLAEN APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD PNNQTTWLFN PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR DSAMPAGTVF QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
  • 基因功能参考文献：
    1. The nucleotide sequence analysis of VP6 gene, encoding inner capsid protein, from selected porcine RVC (PoRVC) strains revealed more than 93% homologies to human RVC strains (HuRVC) of Eurasian origin. PMID: 28643555
    2. These findings elucidate the mechanisms of VP6 adjuvant effect in vivo and support its use as an adjuvant in a combination norovirus and rotavirus vaccine. PMID: 28407442
    3. Data indicate that the recognition site on VP6 as a quaternary epitope containing a high density of charged residues. PMID: 23671563
    4. There is genetic polymorphism in the VP6 gene of porcine RV-C strains in Brazil. PMID: 20391334
  • 亚细胞定位：
    Virion.
  • 蛋白家族：
    Rotavirus VP6 family
  • 数据库链接：

    KEGG: vg:3773139