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  4. Recombinant Reston ebolavirus Membrane-associated protein VP24 (VP24)

Recombinant Reston ebolavirus Membrane-associated protein VP24 (VP24)

  • 中文名称：
    Recombinant Reston ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-YP741753RCJ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Reston ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-EP741753RCJ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Reston ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-EP741753RCJ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Reston ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-BP741753RCJ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Reston ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-MP741753RCJ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VP24
  • Uniprot No.：
  • 别名：
    VP24; REBOVgp6; Membrane-associated protein VP24; Reston VP24; rVP24
  • 种属：
    Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-251
  • 氨基酸序列
    MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
  • 基因功能参考文献：
    1. A more recent discovery is that Reston virus VP24 also binds STAT1 directly, suggesting that VP24 may operate in at least two separate branches of the interferon pathway. PMID: 23076242
    2. VP24 reduces transcription and replication of the Ebola virus genome by direct association with the ribonucleoprotein complex in virus-infected cells. PMID: 17940962
  • 亚细胞定位：
    Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein.
  • 蛋白家族：
    Filoviridae membrane-associated protein VP24 family
  • 数据库链接：

    KEGG: vg:955193