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  4. Recombinant Rat Vasopressin-neurophysin 2-copeptin (Avp)

Recombinant Rat Vasopressin-neurophysin 2-copeptin (Avp)

  • 货号：
    CSB-YP002466RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002466RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002466RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002466RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002466RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AvpVasopressin-neurophysin 2-copeptin; AVP-NPII) [Cleaved into: Arg-vasopressin; Arginine-vasopressin); Neurophysin 2; Neurophysin-I); Copeptin]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    36-128
  • 氨基酸序列
    ATSDM ELRQCLPCGP GGKGRCFGPS ICCADELGCF LGTAEALRCQ EENYLPSPCQ SGQKPCGSGG RCAAAGICCS DESCVAEPEC REGFFRLT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neurophysin 2 specifically binds vasopressin.; Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2).
  • 基因功能参考文献：
    1. Anxiolytic Lactobacillus is found to increase in abundance in inverse proportion to increasing arginine-vasopressin (Avp) gene dosage [most abundant in AVP-deficient Brattleboro (KO) rats]. This genotype effect of Lactobacillus abundance is not found when female rats are analyzed independently. Therefore, Avp deletion affects microbiota composition in a sexually differentiated manner. PMID: 28759308
    2. in the fetal brain whereby vasopressin activates hippocampal interneurons PMID: 29183979
    3. Studies findings imply that arginine vasopressin has a beneficial role for the treatment of cognitive impairments partly through V1a receptor signaling in cerebral hypoperfusion, which is possibly related to improving synaptic plasticity by promoting N-methyl-d-aspartate receptor subunit 2B and postsynaptic density protein externalization and by enhancing autophagy. PMID: 28934194
    4. Data (including data from studies in transgenic rats) suggest diabetes is associated with increased AVP in plasma and in hypothalamic magnocellular neurosecretory cells; electrophysiological recordings in supraoptic nucleus suggest that gamma-aminobutyric acid (GABA) functions as excitatory neurotransmitter in AVP neurons from diabetic rats, whereas it evokes inhibitory responses in AVP neurons from control rats. PMID: 29212780
    5. Vasopressin innervation of the forebrain social behavior neural network undergoes developmental changes and is highly sexually dimorphic. PMID: 28340511
    6. Study shows that acute amphetamine (AMPH) increased vasopressin (AVP) mRNA expression in the medial amygdala, whereas AMPH-induced sensitisation increased AVP mRNA expression in the bed nucleus of the stria terminalis only in females. PMID: 28235136
    7. data suggest that GLP-1 combined with vasopressin could be involved in the regulation of sodium balance in the hyperosmolar state as a result of NaCl loading; vasopressin regulates the reabsorption of a significant portion of filtered sodium in the distal segment of the nephron and modulates the natriuretic effect of GLP-1 PMID: 26791475
    8. Under long term stressed conditions, the release of AVP and OXT from hypothalamus may vary depending on the content of the stressors. Central AVP appears to act oppositely to OXT by mediating CHeS-induced gastric motor maladaptation. Long term central AVP antagonism might be a pharmacological approach for the treatment of stress-related gastric motility disorders. PMID: 27829122
    9. Aroclor-1254 may interfere with the activation of AVP mRNA transcript levels and protein, causing a central dysfunction of vasopressinergic system. PMID: 28579251
    10. This study deminstrated that Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats. PMID: 26939727
    11. The present study suggests that the Avp gene plays an important role in social development. PMID: 27066536
    12. The results of this study showed that arginine vasopressin increases in both sexs rats with aneurysmal subarachnoid hemorrhage. PMID: 26923576
    13. Chronic mild stress increased arginine vasopressin mRNA levels in the paraventricular nucleus. PMID: 26578428
    14. More AVP was expressed in the paraventricular nucleus after rotatory stimulus in rats susceptible to motion sickness (MS). In the ventricular nucleus, AVP expression were low. Of 9 AVP SNPs, rs105235842 differed significantly with MS susceptibility. PMID: 26651338
    15. This data provides the connection between CREB3L1, a newly identified transcription factor of AVP expression. PMID: 26503226
    16. Local cardiac and circulating AVP secretion were enhanced by deteriorating cardiac function. AVP may promote ventricular remodeling. PMID: 25823554
    17. Regression of Walker 256 carcinosarcoma in vasopressin-deficient Brattleboro rats is accompanied by a changed laminin pattern. PMID: 25854851
    18. AVP appears to play a role in the regulation of impulsivity exclusively during lactation. PMID: 25117459
    19. Active coping toward predatory stress decreases DNA methylation in AVP promoter. PMID: 25127982
    20. Identification of AZIN1, and hence by inference, polyamines as novel regulators of the expression of the AVP gene. PMID: 25961839
    21. Vasopressin-deficient rats that are deprived of their mothers as newborns do not exhibit stress and anxiety-like behaviors as adults, probably as a consequence of reduced ACTH rise immediately following maternal deprivation. PMID: 25462910
    22. This study demonstrated that enhanced amygdalar AVP may be related to individual vulnerability to stress-induced reinstatement of heroin- seeking. PMID: 25446223
    23. Supraoptic nucleus neurons consist of two physiologically distinct populations preferentially expressing oxytocin or vasopressin. PMID: 25451978
    24. results unveiled a unique and complex form of neurovascular coupling supporting a competitive balance between nitric oxide and activity-dependent dendritic released vasopressin. PMID: 25834057
    25. The effects of vasopressin on maternal aggression develop in conjunction with impulsivity. PMID: 25001964
    26. Resistance training did not induce any change in vasopressin levels, and atrial natriuretic peptide levels did not change significantly. However, VP increased after the resting period of 15 days. PMID: 23551170
    27. UT-A1 localized to the apical membrane in response to vasopressin was phosphorylated at Ser(486) and Ser(499). PMID: 25377918
    28. eNOS inhibition in spontaneously hypertensive rats induces or enhances an inverse reciprocal interaction between hypothalamus and left ventricle involving the renin-angiotensin system and vasopressin PMID: 24627106
    29. This study is the first to demonstrate dual vasopressin/apelin adaptation mediated by inflammatory molecules and neuronal Trpv2, during aging. PMID: 24505289
    30. The endocannabinoid anandamide decreases basal oxytocin and vasopressin secretion from rat neurohypophysis. PMID: 24342802
    31. We identify CREB3L1 as a regulator of AVP transcription in the rat hypothalamus. PMID: 24623760
    32. Over-expression of CRH and vasopressin in the magnocellular paraventricular nucleus represents a specific feature of anxiety/post traumatic stress disorder-like state. PMID: 24317347
    33. Suggest that the P2X7R is expressed in neurohypophysial terminals and has a role in AVP secretion. PMID: 24037803
    34. The positive role of arginine vasopressin (AVP) in the regulation of adrenocorticotropic hormone secretion from the pituitary in animals exposed to heat is confirmed. AVP from the general circulation influences pituitary vasopressin 1b receptor. PMID: 23580725
    35. Arginine vasopressin-containing neurons of the magnocellular hypothalamic nuclei serve as important sources for hippocampal innervation. PMID: 23085097
    36. The Notch1-Hes1 signalling axis suppresses neuroendocrine differentiation and maintains tubular/acinar features in adenocarcinoma and non-neoplastic epithelium in the biliary tree. PMID: 23523151
    37. Interactions between corticosterone and catecholaminergic projections to the hypothalamus therefore make significant contributions to the regulation of Crh and Avp expression. PMID: 22831701
    38. Leukotrienes may modulate arginine vasopressin secretion. PMID: 22960410
    39. GLP-1 directly stimulated the promoter activities and mRNA levels of both CRF and AVP in hypothalamic 4B cells PMID: 22801106
    40. These results that AVP excites warm-sensitive neurons and inhibits cold-sensitive and temperature-insensitive neurons PMID: 22677202
    41. No difference is found in either quality or quantity of oxytocin- and vasopressin-immunoreactive neurons between individual rats of different social and reproductive ranks. PMID: 22266748
    42. These data demonstrate direct relationships between enhanced AVP neuronal activation and a potentiated vasopressin system, and this latter one with high conditioned anxiety in MS male rats PMID: 22522466
    43. Chronic psychological stress disrupted fasted motility in the antrum and colon via central urocortin 3/arginine vasopression pathways. PMID: 22651925
    44. Vasopressin was more important in the regulation of the adrenocorticotropin secretion in the perinatal vasopressin-deficient Brattleboro rats than in adulthood, where its role depended on the nature of the stressor encountered. PMID: 22527858
    45. In the mammalian peripartum period, the activity of both the brain oxytocin and vasopressin system is elevated as part of the physiological adaptations occurring in the mother--REVIEW PMID: 22100184
    46. We review this and other work demonstrating that both vasopressin and oxytocin modulate conspecific social recognition at the level of the olfactory system--review PMID: 21920364
    47. initial findings suggest that oxytocin and vasopressin systems may mediate early social environment-induced alterations in social behavior--REVIEW PMID: 22197269
    48. AVP can act within multiple regions social behavior network to regulate the expression of individual social behaviors--REVIEW PMID: 22079778
    49. During protracted withdrawal from cocaine, enhanced AVP gene expression is associated with persistent elevations of basal hypothalamus pituitary axis activity. PMID: 21677651
    50. AVP secretion of the pituitary may be involved in the sex differences in susceptibility to motion sickness. PMID: 21171363

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Vasopressin/oxytocin family
  • 数据库链接：

    KEGG: rno:24221

    STRING: 10116.ENSRNOP00000028833

    UniGene: Rn.9976