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  4. Recombinant Rat Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)

Recombinant Rat Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)

  • 货号：
    CSB-YP019042RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019042RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019042RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019042RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019042RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ptpn5; Tyrosine-protein phosphatase non-receptor type 5; EC 3.1.3.48; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MEEKVEDDFL DLDAVPETPV FDCVMDIKPE ADPTSLTVKS MGLQERRGSN VSLTLDMCTP GCNEEGFGYL VSPREESAHE YLLSASRVLR AEELHEKALD PFLLQAEFFE IPMNFVDPKE YDIPGLVRKN RYKTILPNPH SRVRLTSPDP EDPLSSYINA NYIRGYNGEE KVYIATQGPI VSTVVDFWRM VWQERTPIIV MITNIEEMNE KCTEYWPEEQ VVHDGVEITV QKVIHTEDYR LRLISLRRGT EERGLKHYWF TSWPDQKTPD RAPPLLHLVR EVEEAAQQEG PHCSPIIVHC SAGIGRTGCF IATSICCQQL RREGVVDILK TTCQLRQDRG GMIQTCEQYQ FVHHAMSLYE KQLSLQSSE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
  • 基因功能参考文献：
    1. findings suggest that Src and STEP recruitment is contingent on differing intracellular Ca(2+) dynamics that dictate whether NMDAR function is augmented or depressed following M1R stimulation PMID: 27857196
    2. It is involved in the etiology of several age-associated neurologic disorders linked to oxidative stress and is also known to play a role in neuroprotection by modulating glutamatergic transmission. PMID: 27103516
    3. These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD. PMID: 25583483
    4. The findings indicate a neuroprotective role of STEP and suggest a potential role of the STEP-derived peptide in stroke therapy. PMID: 24198371
    5. Previously characterized pathways of STEP regulation via the NMDA receptor are generally conserved in mechanical injury, correlating the amount of STEP formed and the degree of cell death observed after lethal stretch injury. PMID: 22435660
    6. Activation and levels of STEP are dependent on the duration and magnitude of NR2B-NMDA receptor stimulation. PMID: 21029094
    7. RPTPalpha, STEP, and LAR may modulate axon growth. PMID: 15555919
    8. in response to ischemic insults, there are profound reductions in both the amount and the activity of STEP PMID: 18445231
    9. These findings suggest a novel mechanism by which differential NMDAR stimulation regulates STEP(61) to promote either ERK1/2 or p38 activation and identifies calpain cleavage of STEP(61) as a valid target for the development of neuroprotective therapy. PMID: 19625523

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 组织特异性：
    Expressed in the central nervous system except in the cerebellum. Enriched within the striatum relative to other brain areas.
  • 数据库链接：

    KEGG: rno:29644

    STRING: 10116.ENSRNOP00000018860

    UniGene: Rn.10618