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  4. Recombinant Rat Tyrosine-protein kinase FRK (Frk)

Recombinant Rat Tyrosine-protein kinase FRK (Frk)

  • 货号：
    CSB-YP730799RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730799RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730799RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730799RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730799RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Frk
  • Uniprot No.：
  • 别名：
    Frk; GaskTyrosine-protein kinase FRK; EC 2.7.10.2; FYN-related kinase; Gastrointestinal-associated kinase; GASK; Gastrointestinal-associated tyrosine kinase; GTK
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-506
  • 氨基酸序列
    MGSVCMRLWA YLQPFLPCWS QEADKSVVIE NPGAYCPPEA NRSQGQYFVA LFDYEARTAE DLSFHAGDKL QVLDTSHEGW WLARHLEKKG PGLGQQLQGY IPSNYVAEDR SLQAEPWFFG AIKRADAEKQ LLYSENQTGA FLIRESESQK GDFSLSVLDE GVVKHYRIRR LDEGGFFLTR RKTFSTLNEF VNYYTTTSDG LCVKLEKPCL KIQVPTPFDL SYKTVDQWEI DRNSIQLLKR LGSGQFGEVW EGLWNNTTPV AVKTLKPGSM DPNDFLREAQ IMKSLRHPKL IQLYAVCTLE DPIYIITELM RHGSLQEYLQ NDGGSKIRLT QQVDMAAQVA SGMAYLESQN YIHRDLAARN VLVGEHNIYK VADFGLARVF KVDNEDIYES KHEIKLPVKW TAPEAIRTNK FSIKSDVWSF GILLYEIITY GKMPYSGMTG AQVIHMLGQN YRLPQPSNCP EQFYSIMMEC WNVEPKQRPT FETLHWKLED YFEPDSSYSD TNNFIN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
  • 基因功能参考文献：
    1. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
    2. Fyn kinase is associated with sodium channels in brain neurons and can modulate Na(v)1.2 channels by tyrosine phosphorylation after activation of TrkB/p75 neurotrophin receptor signaling by brain-derived neurotrophic factor (BDNF). PMID: 17959796
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  • 组织特异性：
    Highly expressed in stomach, small intestine and colon. Concentrated in the brush border membranes of epithelial cells, throughout the maturation axis of the adult small intestine.
  • 数据库链接：

    KEGG: rno:79209

    STRING: 10116.ENSRNOP00000000653

    UniGene: Rn.10556