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  4. Recombinant Rat Transcriptional regulator ATRX (Atrx)

Recombinant Rat Transcriptional regulator ATRX (Atrx)

  • 货号：
    CSB-YP002437RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002437RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002437RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002437RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002437RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atrx
  • Uniprot No.：
  • 别名：
    AtrxTranscriptional regulator ATRX; EC 3.6.4.12; ATP-dependent helicase ATRX; X-linked nuclear protein; pABP-2; Fragment
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-527
  • 氨基酸序列
    GRSVVEFGDM VCKRQQSAVS SAGSEKPSGK EENVHSPEDK RVTKSKEKSK HLRTRTGRKV KSDVTDRFRK KEQSSESSEG EKKQGRQRTG TRGKKSTDLK EEKVKREREY ESSSDGTEKL PEGEEIGLFS KGVKQNKNDT TDEAKKGKKW KDKSCEKKEE LSDSVDRLPV KGESCDSSED KKTRNRVSLR EKKQFSLPAK SSGKRPECSS SDTERSVKGE CCDSTDKRVK RIDLRERRSS NSKRSTKEVK SGSSSSDAEG SSEDAKKQKK QRMSAKKKNS NTKERKRKSL RATTTKRKQA DITSSSSDIG DDDQNSAGEE SSDEQKIKPV TENLVLPSHT GFCQSSGDEA FSKSVPATVD DDDDDNDPEN RIAKKMLLEE IKANLSSDED GSSDDEPKEG EKKRIGKQSE ETPGDDGSNQ VNSESDSDSE ESKKPRYRHR LLRHKLSLSD GESGGEKKTK PKEHKETKGR NRRKVSSEDS EDTDFQESGV SEEVSESEDE QRPRTRSAKK AELEENQRSY KQKKKRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomeres. May be involved in transcriptional regulation of telomeric repeat-containing RNA (TERRA). Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes.
  • 亚细胞定位：
    Nucleus. Chromosome, telomere. Nucleus, PML body.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 数据库链接：

    STRING: 10116.ENSRNOP00000041679

    UniGene: Rn.107838