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  4. Recombinant Rat Transcription factor 4 (Tcf4)

Recombinant Rat Transcription factor 4 (Tcf4)

  • 货号：
    CSB-YP023302RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023302RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023302RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023302RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023302RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tcf4
  • Uniprot No.：
  • 别名：
    Tcf4; Itf2; Sef2; Transcription factor 4; TCF-4; Immunoglobulin transcription factor 2; ITF-2; RITF-2; R8f DNA-binding protein; SL3-3 enhancer factor 2; SEF-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-589
  • 氨基酸序列
    MTSRDLGSHD NLSPPFANSR IQSKTERGSY SSYGRENVQG CHQSLLGGDM DMGNPGTLSP TKPGSQYYPY SSNNARRRPL HSSTMEVQTK KVRKVPPGLP SSVYAPSAST ADYNRDSPGY SSSKPAASTF SSSFFMQDGH HSSDPWSSSS GMNQPGYGGM LGNSHIPQSS SYCSLHPHER LSYPSHSSAD INSSLPPMST FHRSGTNHYS TSSCTPPANG TDSIMANRGT GAAGSSQTGD ALGKALASIY SPDHTNNSFS SNPSTPVGSP PSLSAGTAVW SRNGGQASSS PNYEGPLHSL QSRIEDRLER LDDAIHVLRN HAVGPSTAVP GGHGDMHGII GPSHNGAMGS LGSGYGTGLL SANRHSLMVG AHREDGVALR GSHSLLPNQV PVPQLPVQSA TSPDLNPPQD PYRGMPPGLQ GQSVSSGSSE IKSDDEGDEN LQDTKSSEDK KLDDDKKDIK SITRSRSSNN DDEDLTPEQK AEREKERRMA NNARERLRVR DINEAFKELG RMVQLHLKSD KPQTKLLILH QAVAVILSLE QQVRERNLNP KAACLKRREE EKVSSEPPPL SLAGPHPGMG DTANHMGQM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.
  • 基因功能参考文献：
    1. TCF4-controlled transcription in primary cortical neurons is induced by neuronal activity and protein kinase A. PMID: 28951451
    2. TCF4 might promote neuronal apoptosis and microglial proliferation after traumatic brain injury PMID: 27090258
    3. expression of Prx1 and Tcf4 is decreased in the developing diaphragm in the nitrofen-induced congenital diaphragmatic hernia in Sprague- Dawley rats animal model. PMID: 27665494
    4. TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 and Scn10a. PMID: 26971948
    5. Chronic constriction injury induced persistent TCF4 upregulation in the dorsal root ganglion and spinal cord. PMID: 25963533
    6. ITF2/Tcf4 enhances follicle-stimulating hormone activity by suppressing the actions of the inhibitors of differentiation (ID)transcription factor proteins and increasing the actions of stimulatory basic helix-loop-helix proteins in Sertoli cells. PMID: 16425294

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: rno:84382

    STRING: 10116.ENSRNOP00000020431

    UniGene: Rn.23354