Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Thyroid hormone receptor alpha (Thra)

Recombinant Rat Thyroid hormone receptor alpha (Thra)

  • 中文名称：
    大鼠Thra重组蛋白
  • 货号：
    CSB-YP023510RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Thra重组蛋白
  • 货号：
    CSB-EP023510RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Thra重组蛋白
  • 货号：
    CSB-EP023510RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Thra重组蛋白
  • 货号：
    CSB-BP023510RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Thra重组蛋白
  • 货号：
    CSB-MP023510RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Thra
  • Uniprot No.：
  • 别名：
    Thra; C-erba-alpha; Nr1a1; Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; c-erbA-1; c-erbA-alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-492
  • 氨基酸序列
    MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQF GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS GILHSRAVCG EDDSSEASSL SSSSSDEDTE VFEDLAGKAA SP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
  • 基因功能参考文献：
    1. This study demonstrated that reduction of the thyroid hormone receptor alfa (Tralpha1)mRNA expression in hippocampus of thyroidectomized Wistar rats. PMID: 26861177
    2. The roles of nitric oxide synthase and TRalph1 in hyperthyroid and hypothyroid rats are reported. PMID: 25726374
    3. down-regulated in hepatocellular carcinoma PMID: 25156012
    4. role for TRalpha1 in the regulation of hypothalamic TRH mRNA expression, whereas TRbeta plays a dominant role in pituitary and liver thyroid hormone metabolism. PMID: 22985455
    5. conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. PMID: 22930759
    6. Data show that acute T3-limiting effect on reperfusion injury is mediated, at least in part, via TRalpha1 receptor. PMID: 21442236
    7. Data show that thyroid hormone induced rat aorta smooth muscle cell proliferation by up-regulating NOX1 in a TRalpha1-dependent manner. PMID: 20414976
    8. Acute myocardial infarction in diabetic rats results in TH receptor down-regulation with important physiological consequences PMID: 20730619
    9. Progression to congestive heart failure after myocardial infarction is associated with suppressed expression of TR alpha 1 and results in tissue hypothyroidism. PMID: 20560106
    10. thyroid hormone and thyroid hormone receptor TRalpha regulate expression of the Na+/H+ exchanger PMID: 12039959
    11. Diurnal changes in liver TR alpha 1 and TR alpha 2 are controlled by the biological clock in the SCN but not via changes in the daily rhythm of food intake PMID: 14657007
    12. role for both the proteosome degradation pathway and altered mRNA stability in T3-induced decrease of nuclear TRalpha1 in the cardiomyocyte PMID: 15498821
    13. These results implicate protein kinase C-alpha as a regulator of thyroid receptor-alpha1 function and suggest that nuclear localization of protein kinase C-alpha may control transcription of the TR alpha gene, and consequently, affect cardiac phenotype. PMID: 16155104
    14. TRalpha2 is a single stranded RNA binding protein; the RNA binding domain localizes to a 41 amino acid region immediately distal to second zinc finger; phosphorylated TRalpha2 is primarily cytoplasmic & unphosphorylated TRalpha2 is primarily nuclear PMID: 16356627
    15. TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart PMID: 16730242
    16. In outer hair cells, TH enhanced the expression of the prestin gene through TRbeta. Simultaneously Kcnq4 expression was activated in the same cells by derepression of TRalpha1. PMID: 16803873
    17. Cardiac dysfunction which occurs at late stages after acute myocardial infarction is associated with increased expression of TR alpha 1 receptor and lower circulating tri-iodothyronine levels. PMID: 17389455
    18. TR-dependent regulatory cascades are controlled differently in organs with a complementary tissue expression pattern and in those with cellular co-expression of the TRalpha and TRbeta genes. PMID: 17496154
    19. TRalpha1 mRNA upregulated in hyperthyroid myocardium and downregulated in hypothyroid myocardium. TRalpha2 mRNA downregulated in hyperthyroid myocardium and upregulated in hypothyroid myocardium. PMID: 18000305
    20. The data show that the expression of thyroid hormone receptor alpha 1 and its mRNA levels were increased by the hypothyroid state. PMID: 18299881
    21. Over-expression of thyroid hormone receptor alpha1 may lead to fetal cardiac phenotype in the absence of thyroid hormone availability. PMID: 18622044
    22. TR alpha 1 and TR beta 1 divergently regulate cardiac pacing activity. TH-induced positive chronotropic effects are likely to be mediated by TR alpha 1 through enhanced expression of I(f) pacemaker current and its underlying genes. PMID: 19629520

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: rno:81812

    STRING: 10116.ENSRNOP00000012340

    UniGene: Rn.11307