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  4. Recombinant Rat Thiomorpholine-carboxylate dehydrogenase (Crym)

Recombinant Rat Thiomorpholine-carboxylate dehydrogenase (Crym)

  • 中文名称：
    Recombinant Rat Thiomorpholine-carboxylate dehydrogenase(Crym),Yeast
  • 货号：
    CSB-YP889894RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Thiomorpholine-carboxylate dehydrogenase(Crym),Yeast
  • 货号：
    CSB-EP889894RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Thiomorpholine-carboxylate dehydrogenase(Crym),Yeast
  • 货号：
    CSB-EP889894RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Thiomorpholine-carboxylate dehydrogenase(Crym),Yeast
  • 货号：
    CSB-BP889894RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Thiomorpholine-carboxylate dehydrogenase(Crym),Yeast
  • 货号：
    CSB-MP889894RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crym
  • Uniprot No.：
  • 别名：
    CrymKetimine reductase mu-crystallin; EC 1.5.1.25; CDK108; NADP-regulated thyroid-hormone-binding protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-313
  • 氨基酸序列
    MRRAPAFLSA DEVQDHLRSS SLLIPPLEAA LANFSKGPDG GVMQPVRTVV PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EGHSNNAVPS HQASVLLFDP SNGSLLAVMD GNVITAKRTA AVSAIATKFL KPPGSDVLCI LGAGVQAYSH YEIFTEQFSF KEVRMWNRTR ENAEKFASSV QGDVRVCSSV QEAVTGADVI ITVTMATEPI LFGEWVKPGA HINAVGASRP DWRELDDELM KQAVLYVDSR EAALKESGDV LLSGADIFAE LGEVVSGAKP AYCEKTTVFK SLGMAVEDLV AAKLVYDSWS SGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
  • 基因功能参考文献：
    1. Results suggest that mu-crystallin may play roles in development of cortical and hippocampal pyramidal cells in the early postnatal period, and in the later period, performs cell-specific functions in selected neuronal populations. PMID: 29603402
    2. CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration. PMID: 24646676
    3. This is the first report linking hyperglycemia with thyroid hormone binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated. PMID: 20018174
    4. Crym protein was predominantly distributed in the fibrocytes in the spiral ligament, as well as the stria vascularis of cochlea in rats. PMID: 18448257
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Ornithine cyclodeaminase/mu-crystallin family
  • 数据库链接：

    KEGG: rno:117024

    STRING: 10116.ENSRNOP00000066476

    UniGene: Rn.24561