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  4. Recombinant Rat Synaptosomal-associated protein 23 (Snap23)

Recombinant Rat Synaptosomal-associated protein 23 (Snap23)

  • 货号：
    CSB-YP021871RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021871RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021871RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021871RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021871RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Snap23
  • Uniprot No.：
  • 别名：
    Snap23; Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-210
  • 氨基酸序列
    MDDLSPEEIQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCVCPCNRT KNFESGKNYK ATWGDGGDSS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA NTRAKKLIDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
  • 基因功能参考文献：
    1. Blocking dephosphorylation at serine 120 residue in SNAP-23 leads to massive inhibition in exocytosis from mast cells. PMID: 29485121
    2. Syntaxin-4 and SNAP23 act as exocytic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to release nerve growth factors from cultured Schwann cells. PMID: 28119011
    3. Electrostatic anchoring precedes stable membrane attachment of SNAP25 and SNAP23 to the plasma membrane. PMID: 28240595
    4. Low expression of SNAP23 in lipid rafts of vascular smooth muscle cells might be a potential cause for hypertension in spontaneously hypertensive rats. PMID: 26930561
    5. SNAP23-VAMP2 interaction plays a key role in cAMP-mediated exocytosis from parotid glands. PMID: 23380067
    6. Annexin A7 may function in co-ordination with SNARE proteins and that protein kinase activation may be required for annexin A7 trafficking. PMID: 22713544
    7. SNAP23 and SNAP25 palmitoylation is regulated by DHHC palmitoyl transferases PMID: 20519516
    8. SNAP-23, but not SNAP-25, is important for the functional regulation of postsynaptic glutamate receptors. PMID: 20118925
    9. We extended our analysis to the SNAP23 homolog; this is expressed at different levels in both gamma-aminobutyric acid-containing terminals (GABAergic) and glutamatergic terminals of the cerebellar cortex. PMID: 19735702
    10. SNAP-23 is expressed in alveolar type II cells of the lung; evidence supports its functional role in exocytosis of lung surfactant by alveolar type II cells. PMID: 15035620
    11. different raft-targeting signals within SNAP-25 and SNAP-23 are likely important for fine-tuning the exocytic pathways in which these proteins operate PMID: 15542596
    12. phosphorylation of SNAP-23 on Ser(120) and Ser(95) modulates regulated exocytosis by mast cells PMID: 15611044
    13. Sensitization with OVA increases the expression in mast cells PMID: 18973100
    14. Report interactions between SNAP23 and aquaporins in inner medullary collecting ducts. PMID: 19515809

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Cytoplasmic vesicle membrane; Peripheral membrane protein.
  • 蛋白家族：
    SNAP-25 family
  • 数据库链接：

    KEGG: rno:64630

    UniGene: Rn.14789