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  4. Recombinant Rat Solute carrier family 22 member 7 (Slc22a7), partial

Recombinant Rat Solute carrier family 22 member 7 (Slc22a7), partial

  • 货号：
    CSB-YP732842RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP732842RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP732842RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP732842RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP732842RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a7
  • Uniprot No.：
  • 别名：
    Slc22a7; Nlt; Oat2; Solute carrier family 22 member 7; Novel liver transporter; Organic anion transporter 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates sodium-independent multispecific organic anion transport. Transport of ketoprofen, indomethacin, salicylate, acetylsalicylate, prostaglandin E2, 3'-azido-3'-deoxythymidine (AZT), 2',3'-dideoxycytidine (ddC), dicarboxylates and p-aminohippurate (PAH).
  • 基因功能参考文献：
    1. the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine PMID: 25904762
    2. strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide PMID: 25710042
    3. Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat. PMID: 21446918
    4. Oat2 mRNA expression was also highest in kidney rather than in liver. Considerably higher Oat2 levels were seen in female kidney as compared with male. PMID: 11907168
    5. In the zona glomerulosa and outer zona fasciculata. Oatp1-3 and OCT2 may be important for endocrine function of rat adrenocortical cells. PMID: 12960058
    6. OAT2 in rat kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation PMID: 16885152
    7. induction of Oatp2 expression in liver of fasted mice may be caused by activation of the cAMP-dependent signaling pathway, with the CRE site (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respectively PMID: 17244698

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed in liver and kidney.
  • 数据库链接：

    KEGG: rno:89776

    STRING: 10116.ENSRNOP00000025094

    UniGene: Rn.10009