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  4. Recombinant Rat Sodium-coupled neutral amino acid transporter 3 (Slc38a3), partial

Recombinant Rat Sodium-coupled neutral amino acid transporter 3 (Slc38a3), partial

  • 货号：
    CSB-YP872833RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP872833RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP872833RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP872833RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP872833RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Slc38a3; Snat3; Sodium-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine and asparagine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
  • 基因功能参考文献：
    1. This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ. PMID: 29561757
    2. Results demonstrate that SNAT3 is functionally active in perisynaptic astrocytes in situ. As a result, astrocytic Nai+ signaling, as would be stimulated by neighboring synaptic activity, has the capacity to stimulate astrocytic glutamine release to support glutamate recycling PMID: 28272791
    3. glucocorticoids regulate acid-base homeostasis during metabolic acidosis in part by regulating expression of the System N transporter SNAT3 PMID: 16954343
    4. Data report that the transport activity of the glutamine transporter SNAT3 is rapidly reduced on PKC activation by phorbol esters via a specific trafficking mechanism in oocytes. PMID: 20739622
    5. SNAT3 is expressed in the placenta in the early stage of pregnancy. PMID: 19892400
    6. regulation of expression of the SN1 amino acid transporter is part of the renal homeostatic response to acid-base imbalance. PMID: 12372777
    7. Ability of SN1 to change transport direction according to changes in gradients of [glutamine] and pH and its sorting to basolateral membranes and presence of putative pH responsive element in 3' untranslated region of gene are conducive to pH regulation. PMID: 15716335
    8. In addition to coupled transport, SNAT3 mediates four modes of uncoupled ion movement across the membrane. PMID: 17148440
    9. catalytic activity of CAII affects the SNAT3 conductance, but presumably not by increasing the local H+ buffer capacity PMID: 17664347
    10. efflux of glutamine was increased when SNAT3 was co-expressed with NBCe1 PMID: 17909850
    11. pronounced expression of SN1 and SAT2 in B-cells and A-cells, respectively, was shown suggesting pronounced expression of SN1 and SAT2 in B-cells and A-cells, respectively. PMID: 19233140
    12. Mutation of asparagine 76 to aspartate rendered the transporter Na+-independent and resulted in a gain of a large substrate-induced chloride conductance in the absence of Na+. PMID: 19596860

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Expressed in skeletal muscle, liver, kidney, heart and brain. Not detected in gut, lung or spleen. Expressed ubiquitously in hepatocytes in liver whereas in kidney expression is restricted to the medulla. Within brain, expressed in glial cells. In the cer
  • 数据库链接：

    KEGG: rno:252919

    STRING: 10116.ENSRNOP00000023623

    UniGene: Rn.32067