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  4. Recombinant Rat Sodium channel and clathrin linker 1 (Sclt1)

Recombinant Rat Sodium channel and clathrin linker 1 (Sclt1)

  • 货号：
    CSB-YP020826RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020826RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020826RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020826RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020826RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sclt1
  • Uniprot No.：
  • 别名：
    Sclt1; Sap1; Sodium channel and clathrin linker 1; Clathrin-associated protein 1A; CAP-1A; Sodium channel Nav1.8-binding protein; Sodium channel-associated protein 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-688
  • 氨基酸序列
    ATEIDLLRD QNVKLNDILR QHQIEHIFRD PAMQNSMSKG GRGDTLTNSV NDQSALPPLI AEYEKHLEEL NRQLTYYQKH MGEMKLQLET VITENERLHS KLKDAVEKQL EALPFGTGIG NDICADDETV RNLQEQLQIA NQEKNWAVQL WQTASQELES VQKLYQEHMT EAQIHVFENR KQKDQLNNFQ QLTKKLHVAN ENIEMTNHHF LKTVTEQNME IEKLRKQLRQ AKLDLRVAVT KVEELTKVTE GLQEQMLKKE EDIMSAQGKE EASDRRVQQL QSSIKQLESR LCIAIQEANV LKTGKTQLEK QIKELQAKCS ESENEKYEAI SRARDSMQLL EEANIKQNQI LLEEKQKEVE REKMKKTISH LIQDAAIKAR KEVESTKKQY EVLILQLKEE LSALQMDCDE KQGQIDRAIR GKRAVEEELE KIYREGKQDE GDYRKLEEMH QRCLAAERSK DDLQLRLKTA ENRIKQLEIN SSEEISRSHE MIQKLQTVLE SERENCGFVS EQRLKLQQEN EQLQKETEDL RKVALEAQKK AKLKVSTMEH QFSIKEHGFE VQLREMEDSN RNSIVELRHL LAAQQKTANR WKEETKKLTE SAEMRISSLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR LQRRLSQAEE RAASASQQLS VITVQRRKAA SMMNLENI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization.
  • 基因功能参考文献：
    1. Coexpression of beta-subunits of NaV1.8 strongly influences the affinity of the muO-conotoxin MrVIB conopeptide for the channel. PMID: 21586605
    2. SAP-1 is the first example of an adapter protein that links clathrin and a sodium channel and may regulate Na(v)1.8 channel density at the cell surface. PMID: 15797711
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 组织特异性：
    Detected in small neurons in dorsal root ganglia. Detected in C-type fibers of sciatic nerve (at protein level).
  • 数据库链接：

    KEGG: rno:266809

    STRING: 10116.ENSRNOP00000019256

    UniGene: Rn.24729