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  4. Recombinant Rat STE20/SPS1-related proline-alanine-rich protein kinase (Stk39)

Recombinant Rat STE20/SPS1-related proline-alanine-rich protein kinase (Stk39)

  • 货号：
    CSB-YP022854RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022854RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022854RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022854RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022854RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stk39
  • Uniprot No.：
  • 别名：
    Stk39; Pask; Spak; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; EC 2.7.11.1; Pancreatic serine/threonine-protein kinase; PS/TK; PSTK1; Serine/threonine-protein kinase 39
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-553
  • 氨基酸序列
    MAEPSGSPVH VQLPQQAAPV TAAAAAPAAA TSAPAPAPAP AAPAAPAPAP AAAPAPAPAA QAVGWPICRD AYELQEVIGS GATAVVQAAL CKPRQERVAI KRINLEKCQT SMDELLKEIQ AMSQCSHPNV VTYYTSFVVK DELWLVMKLL SGGSMLDIIK YIVNRGEHKN GVLEEAIIAT ILKEVLEGLD YLHRNGQIHR DLKAGNILLG EDGSVQIADF GVSAFLATGG DVTRNKVRKT FVGTPCWMAP EVMEQVRGYD FKADMWSFGI TAIELATGAA PYHKYPPMKV LMLTLQNDPP TLETGVEDKE MMKKYGKSFR KLLSLCLQKD PSKRPTAAEL LKCKFFQKAK NREYLIEKLL TRTPDIAQRA KKVRRVPGSS GHLHKTEDGD WEWSDDEMDE KSEEGKAAAS QEKSRRVKEE NPEISVNAGG IPEQIQSLSV HDSQGQPNAN EDYREGPCAV NLVLRLRNSR KELNDIRFEF TPGRDTADGV SQELFSAGLV DGHDVVIVAA NLQKIVDDPK ALKTLTFKLA SGCDGAEIPD EVKLIGFAQL SVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
  • 基因功能参考文献：
    1. in addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation. PMID: 24811174
    2. SPAK and oxidative stress response kinase (OSR1) may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain. PMID: 22238094
    3. roles in phosphorylation and activation of the Na-K-Cl cotransporter (NKCC1) PMID: 12740379
    4. WNK1 and WNK4 both interacted with SPAK as well as a closely related kinase, termed oxidative stress response kinase-1 (OSR1). PMID: 16083423
    5. Two Ste20-like kinases that bind and phosphorylate NKCC1: Ste20-related proline-alanine-rich kinase (SPAK) and oxidative-stress response 1 (OSR1), were identified. PMID: 19307180

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Highly expressed in testis followed by pancreas, kidney, heart and brain. Not expressed in skeletal muscle, liver, lung and spleen.
  • 数据库链接：

    KEGG: rno:54348

    STRING: 10116.ENSRNOP00000034162

    UniGene: Rn.34414