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  4. Recombinant Rat SHC-transforming protein 1 (Shc1)

Recombinant Rat SHC-transforming protein 1 (Shc1)

  • 货号：
    CSB-YP711720RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP711720RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP711720RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP711720RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP711720RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Shc1; SHC-transforming protein 1; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-469
  • 氨基酸序列
    MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGAMRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEELPDHQYY NDFPGKEPPL GGVVDMRLRE GAARPTLPST QMPSHLGATL PIGQHVTGDH EVRKQMLPPP PCPGRELFDD PSYVNIQNLD KARQAGGGAG PPNPSVNGSA PRDLFDMKPF EDALRVPPAP QSMSMAEQLQ GESWFHGKLS RREAEALLQL NGDFLVREST TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT KDHRFESVSH LISYHMDNHL PIISAGSELC LQQPVDRKV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
  • 基因功能参考文献：
    1. inactivation of the adaptor protein p66Shc decreases afferent arteriolar KATP channel activity and decreases renal damage in diabetic salt-sensitive rats. PMID: 30131395
    2. Our studies revealed that Coenzyme Q10 strongly inhibits nicotine-mediated production of reactive oxygen species and consequent apoptosis that requires serine36 phosphorylation but not mitochondrial translocation/cytochrome c binding of p66(shc). PMID: 27770269
    3. a pivotal role for p66(shc) -induced vascular dysfunction in a common pathogenic cascade shared by noise-induced and age-related hearing loss, is reported. PMID: 27157635
    4. Data suggest that, in a renal proximal tubule cell line, p66shc plays dual roles in promoting toxic effects of high-concentration of alpha-tocopherol; p66shc both promotes oxidative stress and suppresses the pro-survival ERK/CREB/HO-1 signaling pathway. PMID: 28155123
    5. p66Shc is a regulator of renal vascular tone and a driver of impaired renal vascular function in hypertension-induced nephropathy PMID: 27270176
    6. SIRT1 inhibition significantly abrogated the suppression of p66Shc expression. PMID: 26845416
    7. The results support a link between liver cell apoptosis and the miR-34a/SIRT1/p66shc pathway, which can be modulated by carnosic acid in nonalcoholic fatty liver disease. PMID: 26203862
    8. p53-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity PMID: 25810038
    9. that p52SHC3 plays an important role in maintaining the mitotic quiescence of neurons, while p52SHC1 regulates the proliferation of neural stem cells PMID: 26058566
    10. Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate. PMID: 24085465
    11. Data suggest that vascular activity of penile/cavernosal tissue is impaired by upregulation of p66Shc and Bip/Hspa5 (Ig heavy-chain binding protein/heat shock protein 5) in diabetic corpus cavernosum of penis leading to erectile dysfunction. PMID: 23215692
    12. p66-Shc gene expression is specifically up-regulated in the aged liver and brain. PMID: 22130185
    13. This is the first work to demonstrate the essential role of p66(shc) in mediating requisite mitochondrial and energetic compensation after preconditioning and suggests a mechanism by which protein and organelle damage mediated by ROS can increase HSP70. PMID: 20392947
    14. The Shc1 signal pathway if critical in angiotensin II-dependent smooth muscle vascular endothelial cell division. PMID: 12837289
    15. data show that the regulation of Shc mRNAs in senescence is region as well as isoform specific PMID: 12882334
    16. p66Shc isoform exerts an inhibitory effect on the mitogen-activated protein kinase signaling pathway in rodent myoblasts. PMID: 15262993
    17. conclude that the expression of p66Shc protein is regulated by signaling through the thyrotropin receptor in proliferating thyroid cells PMID: 15705774
    18. p66(shc) regulates mitochondrial oxidative capacity and may extend life span by repartitioning metabolic energy conversion away from oxidative and toward glycolytic pathways PMID: 16481327
    19. A functional role for Shc and likely FRS2 in ALK-dependant MAP-kinase activation and neuronal differentiation of PC12 cells. PMID: 17274988
    20. the increased phosphorylation of p66shc is one of the important mediators in the impaired endothelium-dependent relaxation of aortic coarctation rats. PMID: 18588882
    21. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. PMID: 19060130
    22. p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. PMID: 19168439

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: rno:85385

    STRING: 10116.ENSRNOP00000028038

    UniGene: Rn.138818