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  4. Recombinant Rat Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

Recombinant Rat Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

  • 货号：
    CSB-YP717284RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP717284RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP717284RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP717284RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP717284RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Erbb3Receptor tyrosine-protein kinase erbB-3; EC 2.7.10.1; Proto-oncogene-like protein c-ErbB-3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
  • 基因功能参考文献：
    1. While no changes occur for ErbB2, ErbB4 and Nrg1, an increase of ErbB3 expression occurs after I/R injury, with and without PostC. PMID: 28162790
    2. NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro. PMID: 27113200
    3. Sox2 promotes satellite glial cell survival through the MAPK pathway via Erbb2-Erbb3 receptors. PMID: 26116536
    4. we demonstrated the involvement of ErbB receptors in the regulation of neurite elongation and sodium current induction in PC12 cells PMID: 23380500
    5. Binding of L1CAM to erbB enhances its response to neuregulins. PMID: 22815787
    6. Alternative transcription initiation results in the formation of a nuclear variant of ErbB3 in rat primary Schwann cells. PMID: 21451047
    7. ErbB3 may participate in tooth morphogenesis PMID: 12112465
    8. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. PMID: 12838503
    9. Dexamethasone exerts a time-dependent and redundant inhibitory effect on Egfr-mediated proliferative signaling in hepatocytes, targeting ErbB proteins and their positive/negative effectors. PMID: 17585012
    10. The erbB3 expression was significantly elevated in well-differentiated carcinoma in normal animals. PMID: 17704947
    11. disruption of surface HSP90/HER-2 interaction leads to inhibition of heregulin-induced HER-2-HER-3 heterodimer formation, reduced HER-2 phosphorylation, and impaired downstream kinase signaling. PMID: 18056992
    12. Data show that the expression of ErbB3 mRNAs is upregulated after end-to-end and end-to-side nerve regeneration in the rat median nerve model. PMID: 18845940

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
  • 数据库链接：

    KEGG: rno:29496

    STRING: 10116.ENSRNOP00000006796

    UniGene: Rn.10228