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  4. Recombinant Rat Proton-coupled amino acid transporter 1 (Slc36a1), partial

Recombinant Rat Proton-coupled amino acid transporter 1 (Slc36a1), partial

  • 中文名称：
    大鼠Slc36a1重组蛋白
  • 货号：
    CSB-YP852875RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc36a1重组蛋白
  • 货号：
    CSB-EP852875RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc36a1重组蛋白
  • 货号：
    CSB-EP852875RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc36a1重组蛋白
  • 货号：
    CSB-BP852875RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc36a1重组蛋白
  • 货号：
    CSB-MP852875RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc36a1
  • Uniprot No.：
  • 别名：
    Slc36a1; Lyaat1; Pat1; Proton-coupled amino acid transporter 1; Proton/amino acid transporter 1; Lysosomal amino acid transporter 1; LYAAT-1; Neutral amino acid/proton symporter; Solute carrier family 36 member 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neutral amino acid/proton symporter. Probably involved in the efflux of lysosomal proteolysis products such as L-proline, L-alanine and glycine from the cell. May play a role in specifying sites for exocytosis in neurons.
  • 基因功能参考文献：
    1. Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport. PMID: 23962042
    2. knockdown of (PAT1) led to induced cellular growth, suggesting a role for PAT1 in regulating cellular proliferation of smooth muscle cells PMID: 24222668
    3. Expression of proton-assisted amino acid transporter 1 (PAT1) mRNA was slightly but not significantly induced by a single bout of exercise in soleus and extensor digitorum longus muscles. PMID: 24016666
    4. PAT1(Slc36a1) protein was present in rat rectal epithelium. PMID: 22234618
    5. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. PMID: 12598615
    6. The essential role of chloride and fructose absorbing Slc36a1 is reported. PMID: 18496516

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Widely expressed and predominantly expressed in brain. Within the brain, expression restricted to neurons and not detected in glial cells. Abundant in regions rich in neurons using glutamate and GABA such as Purkinje cells in the cerebellum and pyramidal
  • 数据库链接：

    KEGG: rno:155205

    STRING: 10116.ENSRNOP00000016755

    UniGene: Rn.76305