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  4. Recombinant Rat Protein fem-1 homolog A (Fem1a)

Recombinant Rat Protein fem-1 homolog A (Fem1a)

  • 货号：
    CSB-YP706303RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP706303RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP706303RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP706303RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP706303RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fem1a
  • Uniprot No.：
  • 别名：
    Fem1a; Protein fem-1 homolog A; FEM1a; FEM1-alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-654
  • 氨基酸序列
    MDLHTAVYNA AHDGKLLLLQ KLLAGRGREE IEELLGEVAG GGTPLLIAAR RGHLDVVEYL VDNCGASVEA SGSVHFDGET IEGAPPLWAA SAAGHLAVVR SLLRRGASVN RTTRTNSTPL RAACFDGHLD VVRYLVGEHK ADLEVANRHG HTCLMISCYK GHREIARYLL ERGAQVNRRS AKGNTALHDC AESGSLEILQ LLLGCHARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG HGQLSGTELP GEGSSQMAGN HCSTPEEAEP YESCCPTSRE AAVEALELLG ATYVDKKRDL LGALKHWRRA MELRHQGGDY LPKPEPQQLV LAYDYSREVS TPQELEALIT DPDEMRMQAL LIRERILGPS HPDTSYYIRY RGAVYADSGN FERCIRLWKY ALDMQQNNLE PLSPMTASSF LSFAELFSYV LQDRSAKGNL GMQLGFADLM GVLSKGVREV ERALQLPKEP GDSAQFTKAI AIILHLLYLL EKVECTPSQE HLKHQTVYRL LKCAPRGKNG FTPLHMAVDK ETTNVGRYRV GIFPSLQVVK VLLDCGADPD SRDFDNNTPL HVAAQNNCPA IMDALIEAGA HMDATNAFKK TAYELLDSKL LAKSTMQPFN YVTLQCLAAR ALDRNKVPYK GFIPEELEAF IQLH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
  • 亚细胞定位：
    Mitochondrion. Cytoplasm.
  • 蛋白家族：
    Fem-1 family
  • 数据库链接：

    KEGG: rno:316131

    STRING: 10116.ENSRNOP00000067295

    UniGene: Rn.228392