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  4. Recombinant Rat Protein-arginine deiminase type-4 (Padi4)

Recombinant Rat Protein-arginine deiminase type-4 (Padi4)

  • 货号：
    CSB-YP017379RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017379RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017379RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017379RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017379RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Padi4
  • Uniprot No.：
  • 别名：
    Padi4; Pad4; Pdi4Protein-arginine deiminase type-4; EC 3.5.3.15; PAD-R4; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-666
  • 氨基酸序列
    MAQGAVIHVA PEEPTHAVCV VGTATPLDIR GSAPRGSTSF SITASPEVVV DVIHGPPSKK STTGASKWPL DPKLEVTLQM KAASSRIDDQ KVRISYYGPK TSSTQALLYL TGVELSLSAD VTRTGKAKPA PAGKDQSTWT WGPDGHGAIL LVNCDKEDPK SSGMDFEDDK VLDNKDLQDM SPMTLSTKTP KDFFDKYQLV LQVPKAKMNK VRVFRATRGK LPSRYKVVLG PQQFSHRLEL LGGQHSTDFY VEGLAFPDAD FKGLIPLTIS LLDKSNPELP EALVFQDTVM FRVAPWIMTP NTQPPQEVYV CRFSDNEDFL KSLATFTKKA KCKLTVCPEE ENQDDQWMQD EMEIGYIQAP HKTLPVVFDS PRDRGLKDFP VKRVMGPNFG YVTRGLYRAE VTGLDAFGNL EVSPPVTVRG KEYPLGRILI GSSGYSSSES RDMHQILQDF LGAQQVQAPV RLFSDWLFVG HVDEFLSFVP ARGKQGFRLL LSSPRACYQM FQELQTEGHG EASLFEGLKR KRQTISDILS SQKLRDQNAY VESCIDWNRE VLKRELGLTE GDIIDIPQLF RIVGNSRGNP KAEAFFPNMV NMLVLGKHLG IPKPFGPIIN GRCCLEEKVC SLLEPLGLHC TFINDFYSYH MYHGEVHCGT NVRRKPFAFK WWHMVP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasmic granule.
  • 蛋白家族：
    Protein arginine deiminase family
  • 组织特异性：
    Epidermis.
  • 数据库链接：

    KEGG: rno:29512

    STRING: 10116.ENSRNOP00000009081

    UniGene: Rn.11155