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  4. Recombinant Rat Protein BTG2 (Btg2)

Recombinant Rat Protein BTG2 (Btg2)

  • 货号：
    CSB-YP002864RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002864RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002864RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002864RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002864RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Btg2; Pc3Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-158
  • 氨基酸序列
    MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK NYVMTVSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
  • 基因功能参考文献：
    1. PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. PMID: 27333946
    2. the present study provides us with a novel molecular mechanism of BTG2-mediated induction of hepatic gluconeogenesis and suggests that BTG2 plays an important role in hepatic glucose metabolism. PMID: 23058912
    3. Math1 was expressed on postnatal days 0 - 5 in rat greater epithelial ridge cells. PMID: 16335396
    4. These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea. PMID: 19997037
    5. PC3 potentiates the induction of neuronal markers tyrosine hydroxylase and neurofilament 160 kDa protein, enhances nerve growth factor-induced differentiation and protects neurons from apoptosis. PMID: 11930152
    6. BTG2(TIS21/PC3) expression promotes neuronal differentiation and that it is required for survival of terminally differentiated cells. PMID: 12360398
    7. The role of NO in the enteric system is discussed with respect to neuronal nitric oxide synthase expression in neurons associated with the gut and the nerve growth factor and its receptor, tyrosine kinase A expression in the lamina epithelialis. PMID: 16191397
    8. A rat PC3 gene expressed in transgenic mice may prevent medulloblastoma development by controlling cell cycle and promoting differentiation of cerebellar granule cell precursors. PMID: 17371797
    9. PC3/Tis21/BTG2 is essential for terminal differentiation of neural progenitors. Genetic ablation of PC3/Tis21/BTG2 impairs terminal differentiation and shortens G1 phase of cell cycle duration of neural progenitor cells. PMID: 20020054
    10. PC3/Tis21/BTG2 promotes differentiation of neural cells and protects neurons from apoptosis. PMID: 11930152
    11. PC3/Tis21/BTG2 is a tumor suppressor of medulloblastoma PMID: 17371797
    12. The gene PC3/Tis21/BTG2 binds the histone deacetylases HDAC4 and HDAC1 and, as detected by chromatin immunoprecipitation, associates directly to the cyclin D1 promoter where it is likely to recruit the histone deacetylases. PMID: 17371797
    13. The gene BTG2/Tis21/PC3 inhibits cyclin D1 transcription and is a G1-S cell cycle phase checkpoint PMID: 10669755
    14. A comprehensive review of the different properties of the gene BTG2/Tis21/PC3 PMID: 11267995
    15. The gene PC3/Tis21/BTG2 potentiates the NGF-induced neural differentiation in vitro PMID: 11930152
    16. The gene BTG2/Tis21/PC3 induces the differentiation in vivo of cerebellar neural progenitors, acting on the transcription of the proneural gene Math1 PMID: 15056715

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  • 蛋白家族：
    BTG family
  • 组织特异性：
    In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.
  • 数据库链接：

    KEGG: rno:29619

    STRING: 10116.ENSRNOP00000004408

    UniGene: Rn.27923