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  4. Recombinant Rat Paxillin (Pxn)

Recombinant Rat Paxillin (Pxn)

  • 货号：
    CSB-YP019112RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019112RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019112RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019112RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019112RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pxn; Paxillin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-586
  • 氨基酸序列
    MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG TVLDPLDQWQ PSGSRYAHQQ PPSPSPIYSS STKNSSASNP QDSVGSLCSR AGEEEHVYSF PNKQKSAEPS PTVMSSSLGS NLSELDRLLL ELNAVQRSPS GFSAGMVSVQ ASREPLGSWG TEGRAIILSP FFQDEAESSP PLPGALSPLY GVPESNNLLG GKAGPLMKEK PKRNGGRGLE DVRPSVESLL DELENSVPSP VPAITVNQGE MSSPQRVTSS QQQTRISASS ATRELDELMA SLSDFKFMAQ GKTGSSSPPG GLSKPGSQLD SMLGSLQSDL NKLGVATVAK GVCGACKKPI AGQVVTAMGK TWHPEHFVCT HCQEEIGSRN FFERDGQPYC EKDYHSLFSP RCYYCNGPIL DKVVTALDRT WHPEHFFCAQ CGAFFGPEGF HEKDGKAYCR KDYFDMFAPK CGGCARAILE NYISALNTLW HPECFVCREC FTPFVNGSFF EHDGQPYCEV HYHERRGSLC SGCQKPITGR CITAMAKKFH PEHFVCAFCL KQLNKGTFKE QNDKPYCQSC FLKLFC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
  • 基因功能参考文献：
    1. downregulation of paxillin results in inhibition of dysregulation of cytoskeletal proteins and proliferation of pulmonary artery smooth muscle cells, suggesting a potential therapeutic effect on pulmonary vascular remodelling in Hepatopulmonary syndrome PMID: 24457422
    2. The dynamic expression of paxillin in rat pancreas from different stages indicates that paxillin might be involved in some aspects of pancreatic development. PMID: 22110278
    3. In mesenteric arteries an intact cytoskeleton and force development are necessary for the translocation of PYK2 and paxillin to the membrane PMID: 15911746
    4. Paxillin-S273 phosphorylation dramatically increases migration, protrusion, and adhesion turnover by increasing paxillin-GIT1 binding and promoting the localization of a GIT1-PIX-PAK signaling module near the leading edge. PMID: 16717130
    5. Paxillin associated with clustered IgE-Fc epsilonRI has a net positive effect on Fc epsilonRI signaling. PMID: 19004813
    6. Data show that CXCL8 stimulation leads to paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors (CXCR1 and CXCR2) mediate CXCL8-induced paxillin phosphorylation. PMID: 19151925

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex.
  • 蛋白家族：
    Paxillin family
  • 数据库链接：

    KEGG: rno:360820

    STRING: 10116.ENSRNOP00000043928

    UniGene: Rn.75