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  4. Recombinant Rat P2X purinoceptor 1 (P2rx1), partial

Recombinant Rat P2X purinoceptor 1 (P2rx1), partial

  • 货号：
    CSB-YP017319RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017319RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017319RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017319RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017319RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    P2rx1; P2X purinoceptor 1; P2X1; ATP receptor; Purinergic receptor; RP-2 protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.
  • 基因功能参考文献：
    1. Indicate a predominant role for P2X1R and P2X7R in the control of glomerular hemodynamics in ANG II hypertension. PMID: 28404593
    2. Study demonstrated that P2X1 receptor-mediated calcium ion influx triggered by DA-9801 potentiated the Nerve Growth Factor-induced neurite outgrowth. The results obtained in this study imply a possible relationship between P2X1 and neuroregeneration. PMID: 27442785
    3. work identified that in major arteries of rat cerebral circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4 receptors subunits. PMID: 26481522
    4. P2X1, P2X2, P2X3, and P2X4 receptor subunits are expressed differently in rat nodose ganglion neurons PMID: 24798490
    5. heteromeric P2X1/4Rs contribute to the sustained component of the purinergic-mediated vasoconstriction in rat middle cerebral arteries. PMID: 25070962
    6. Trigeminal ganglion neurons functionally express P2X, P2X, and P2X receptors and that these receptors are involved in the mediation of not only nociceptive but also neuropathic pain in the orofacial area. PMID: 22785548
    7. analysis of involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor PMID: 22745172
    8. The P2X1 and P2X3 subunits are detected in neuropils in the superficial layer of the rat dorsal horn. PMID: 21669492
    9. evidence that 2 types of purinoreceptors are functional in renal vascular smooth muscle cells: monomeric P2X1 receptors and heteromeric P2X1/P2X4 receptors PMID: 20590593
    10. P2X(1) receptor activation is important for whole kidney autoregulation in vivo. PMID: 20335318
    11. The vagal nerve sections leads to increassed levels of p2x1 receptor in the dorsal vagal nucleus, but not in the nucleus ambiguus. PMID: 12788520
    12. immunostaining of pancreas from streptozotocin-diabetic rats revealed P2X1, P2X2, P2Y1 and P2Y2 receptors present in small blood vessels. PMID: 12850289
    13. results suggest that the P2X1 ectodomain confers nanomolar ATP sensitivity PMID: 14625300
    14. P2X1 receptors have a role in renal microvascular autoregulatory behavior PMID: 14679185
    15. In rat retina, somatostatin-containing neurons are labeled by purinergic P2X1 receptors. PMID: 15174083
    16. Change in Ca2+transients is not due to a decrease in P2X1 receptor density in the smooth muscle cell membranes. PMID: 15227655
    17. Data provide biochemical evidence that in addition to the rapidly desensitising P2X1 and P2X3 receptors, the slowly desensitising subtypes P2X2, P2X4, and P2X5 are trimers of identical subunits. PMID: 15313628
    18. Involved in nociceptive transmission to lamina I neurons. PMID: 15813988
    19. ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus, the facilitation being mediated by P2X1, P2X2/3, and P2X3. PMID: 16000618
    20. Results suggest that lipid rafts play an important role in P2X1 receptor-mediated control of arteries. PMID: 16006561
    21. An investigation into interactions bseen this and nicotinic recepetors in rat hippocampus. PMID: 17192669
    22. An almost complete cross-link into trimers was seen with the K68C/F291C double mutant, consistent with formation of intersubunit disulfide bridges near the ATP binding site. Loops from neighboring P2X subunits form the ATP-binding site in P2X receptors. PMID: 17287520
    23. The level of myometrial P2X1 receptor expression remains low throughout pregnancy, but is greatly up-regulated at day 22. PMID: 17561003
    24. These results indicate that phosphatidylinositol 4,5-bisphosphate plays a key role in the expression of full native and heterologous P2X(1) function by regulating the amplitude, recovery, and kinetics of ionotropic ATP responses. PMID: 18523136
    25. This work demonstrates that P2X receptor activation enhances inhibitory neurotransmission to parasympathetic cardiac vagal neurons and demonstrates an important functional role for ATP mediated purinergic signaling to cardiac vagal neurons. PMID: 18590708
    26. Results show that the myocardium of 14- to 100-day-old rats contains functionally active P2X1 receptors, which are involved in the positive inotropic effect of the atria and ventricles. PMID: 19023961
    27. In summary, fibrosarcoma cells release diffusible factors altering the properties of desensitization kinetics of P2X receptors and, in particular, decrease their sensitivity to opioid inhibitory control PMID: 19077126

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 组织特异性：
    High levels in vas deferens and urinary bladder. Lower extent in spinal cord, coeliac ganglion, lung and spleen (probably in the smooth muscle part of both organs).
  • 数据库链接：

    KEGG: rno:25505

    STRING: 10116.ENSRNOP00000024068

    UniGene: Rn.91176