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  4. Recombinant Rat Neuromedin-U (Nmu)

Recombinant Rat Neuromedin-U (Nmu)

  • 货号：
    CSB-YP319447RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP319447RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP319447RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP319447RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP319447RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nmu
  • Uniprot No.：
  • 别名：
    Nmu; Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36; NURP36); Neuromedin precursor-related peptide 33; NURP33); Neuromedin-U-23; NmU-23)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    144-166
  • 氨基酸序列
    YKVNEYQ GPVAPSGGFF LFRPRN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for receptors NMUR1 and NMUR2. Receptor-binding is very tight if not irreversible and triggers an increase in the cytosolic Ca(2+) concentration. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
  • 基因功能参考文献：
    1. PEGylated rat NMU-8 showed potent and robust anorectic activity and anti-obesity effect in diet-induced obesity mice. PMID: 28400225
    2. These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU. PMID: 26826380
    3. The results demonstrated that, when injected into the lateral brain ventricle NmU increased the body temperature, mediated by CRHR1 and CRHR2, dopamine and muscarinic cholinergic receptors. PMID: 25108055
    4. study of NMU signalling reveals the potential for a new player in the control of seasonal biology PMID: 24164054
    5. Melatonin negatively regulates neuromedin U mRNA expression in the rat pars tuberalis. PMID: 23843987
    6. Functional evidence that NMU can have an important effect on the cardiovascular and reflex responses that are integrated in the rostral ventrolateral medulla. PMID: 23538213
    7. NMU and NMU receptor 2 compose a novel autocrine system in theca/interstitial cells in which the intensity of signaling is tightly controlled by gonadotropins. PMID: 23423171
    8. Functional evidence is presented describing a complex differential modulatory activity of NMU on cardiovascular and reflex responses that are integrated in the rostral ventrolateral medulla. PMID: 22262923
    9. novel role for neuromedin U in the paraventricular nucleus to stimulate the hypothalamo-pituitary-adrenal axis and locomotor and grooming behavior and to inhibit feeding PMID: 12399416
    10. Effects of neuromedin U on gastric acid functions via the corticotropin-releasing hormone pathway in conscious rats PMID: 12584108
    11. NMU selectively depolarizes the subpopulation of PVN parvocellular neurons via enhancement of the hyperpolarization-activated inward current. PMID: 12711715
    12. Results indicate that neuromedin U may play some important role in the circadian oscillator by exerting an autocrine or paracrine action in the suprachiasmatic nucleus. PMID: 15110767
    13. Neuromedin U acts on the presynaptic terminals of the primary afferent fibers working as an autocrine/paracrine neuromodulator to increase the frequency of miniature excitatory postsynaptic currents of the substantia gelatinosa and deep layer neurones. PMID: 15297576
    14. Central NMU may be involved in stress-induced activation of CRF-containing neurons in the paraventricular nucleus. PMID: 15512854
    15. NMU is positively associated with nonexercise activity thermogenesis via actions in the PVN and arcuate nucleus. Paraventricular NMU also significantly decreased food intake, as well as body weight. PMID: 16867180
    16. Neuromedins U and S may play different roles in the functional regulation of neuroendocrine axes. PMID: 17611645
    17. Taken together with previous studies, these results suggest that obesity may represent a state associated with decreased central sensitivity to neuropeptides such as NMU that increase physical activity and therefore energy expenditure. PMID: 17706946
    18. Neuromedin U has a predominant stimulatory role in control of the female gonadotropic axis, which appears under the influence of developmental, hormonal, and photoperiodic cues. PMID: 17726140
    19. Challenge of either circular or longitudinal rat isolated colonic smooth muscle preparations with NmU resulted in robust contractions, highlighting a major discrepancy in the behavior of NmU in single cells and in intact tissues PMID: 18180374
    20. Findings demonstrate that exogenous NMU may stimulate proliferation primarily of the cortical zona glomerulosa cells in rats administered with ACTH, although at high doses of exogenous corticotropin an opposite effect occurred. PMID: 19082512

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  • 亚细胞定位：
    [Neuromedin-U-23]: Secreted.
  • 蛋白家族：
    NmU family
  • 组织特异性：
    Expressed throughout the gastrointestinal tract with highest levels in the duodenum and jejunum. Low levels in spinal cord, hypothalamus, and stomach. Neuromedin-U-23: Expressed in the small intestine and the pituitary gland (at protein level). Neuromedin
  • 数据库链接：

    KEGG: rno:63887

    STRING: 10116.ENSRNOP00000002941

    UniGene: Rn.47720