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  4. Recombinant Rat Myocyte-specific enhancer factor 2D (Mef2d)

Recombinant Rat Myocyte-specific enhancer factor 2D (Mef2d)

  • 货号：
    CSB-YP013674RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013674RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013674RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013674RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013674RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mef2d; Myocyte-specific enhancer factor 2D
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-507
  • 氨基酸序列
    MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSSVPAPNF AMPVTVPVSN QSSMQFSNPS SSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA SAGAMLGRDL NSANGACPNP VGNGYVSARA SPGLLPVANG NGLNKVIPAK SPPPPTHNTQ LGAPSRKPDL RVITSQGGKG LMHHLNNAQR LGVSQSTHSL TTPVVSVATP SLLSQGLPFS SMPTAYNTDY QLPSAELSSL PAFSSPAGLA LGNVTAWQQP QQPQQPQPPQ PPQSQPQPPQ PQPQQPPQQQ PHLVPVSLSN LIPGSPLPHV GAALTVTTHP HISIKSEPVS PSRERSPAPP PPAVFPAARP EPGEGLSSPA GGSYETGDRD DGRGDFGPTL GLLRPAPEPE AEGSAVKRMR LDTWTLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
  • 基因功能参考文献：
    1. Study suggests that SU4312 provides therapeutic benefits in cellular and animal models of Parkinson's disease, possibly through multiple mechanisms including enhancement of myocyte enhancer factor 2D through the activation of PI3-K/Akt pathway. PMID: 28807675
    2. MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process. PMID: 28473466
    3. MEF2D has a critical role in cell cycle regulation of post-mitotic, neonatal cardiomyocytes in vitro PMID: 26294766
    4. dysregulation of MEF2D by calpain may mediate excitotoxicity via an extrasynaptic NMDAR-dependent manner PMID: 22215669
    5. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. PMID: 20816781
    6. These results suggest that PC12 cell death by 6-OHDA appears to be regulated by the down-regulation of MEF2D via some interaction between cdk5 and MAP kinase. PMID: 21057871
    7. Atorvastatin reverses hypertension-induced cardiac remodeling partially through down-regulation of PKD/MEF2D activation. PMID: 19683055
    8. TEF-1 and MEF2 (Mef2d) transcription factors interact to regulate cardiac myocyte-specific promoters. PMID: 12061776
    9. a novel role of MEF2 as a key nuclear mediator that may participate in the pathologic process of liver fibrogenesis in vivo. PMID: 15480995
    10. MEF2 is a target of cAMP-PKA pathway and PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival PMID: 15735306
    11. These results suggest that JMJ represses alphaMHC expression via protein-protein interaction with MEF2A. PMID: 15737621
    12. Muscle contraction leads to a rapid increase of MEF2D mRNA. PMID: 16024167
    13. results show that MEF2 transcription factors negatively regulate excitatory synapse number in an activity-dependent manner during synaptic development in vitro PMID: 16484497
    14. cAMP interferes with MEF2D-mediated gene expression at multiple levels by antagonizing the derepression of MEF2D by HDAC5 and by inhibiting recruitment of the co-activator NFAT. PMID: 16870618
    15. MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length. PMID: 17945419
    16. MEF2D is a novel downstream effector targeted by GSK3beta PMID: 19801631

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: rno:81518

    STRING: 10116.ENSRNOP00000041061

    UniGene: Rn.89018