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  4. Recombinant Rat Lithostathine (Reg1)

Recombinant Rat Lithostathine (Reg1)

  • 货号：
    CSB-YP320789RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP320789RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP320789RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP320789RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP320789RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Reg1
  • Uniprot No.：
  • 别名：
    Reg1; Reg; Lithostathine; Islet cells regeneration factor; ICRF; Islet of Langerhans regenerating protein; REG; Pancreatic stone protein; PSP; Pancreatic thread protein; PTP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-165
  • 氨基酸序列
    QEAEEDLPS ARITCPEGSN AYSSYCYYFM EDHLSWAEAD LFCQNMNSGY LVSVLSQAEG NFLASLIKES GTTAANVWIG LHDPKNNRRW HWSSGSLFLY KSWDTGYPNN SNRGYCVSVT SNSGYKKWRD NSCDAQLSFV CKFKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Might act as an inhibitor of spontaneous calcium carbonate precipitation.
  • 基因功能参考文献：
    1. The positive correlation between Reg1a and Tgfb1 genes expression was determined in the dynamics of stress-induced gastric lesions development and healing, which may indicate the involvement of Tgfb1 in acceleration of lesions healing. PMID: 29537200
    2. The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas. PMID: 28415799
    3. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. PMID: 23544109
    4. After duodenal-jejunal bypass, the level of Reg1 protein was reduced in bypassed duodenum in morbidly obese Zucker fatty rats. PMID: 23370676
    5. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
    6. examination of signaling pathway in gastric cancer cells and effect on cell proliferation PMID: 12387866
    7. PSP/reg and pancreatitis associated proteins are coordinately regulated secretory stress proteins. PMID: 15100001
    8. Damaged heart may be a target for Reg action, and Reg may protect against acute heart stress. PMID: 15778284
    9. Acute pancreatitis results in increased tissue reg I protein levels in the pancreas, as well as a threefold induction of reg I receptor. Induction of reg I and its receptor may be important for recovery from acute pancreatitis. PMID: 16874863
    10. Pancreatic-derived cells exposed to reg I grow by activation of signal transduction pathways involving the mitogen-activated protein kinase phosphatases and cyclins, with concomitant induction of MKP-1. PMID: 18929742
    11. Depletion of the acinar product reg I is associated with the pathogenesis of impaired glucose tolerance of pancreatitis-associated diabetes and aging, and replacement therapy could be useful in these patients. PMID: 18953250
    12. These results demonstrate that Reg I is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration. PMID: 19284990
    13. Reg I expression in acinar cells is important in maintaining pancreatic cell lineage, and when decreased, cells can dedifferentiate and move toward becoming other pancreatic cells. PMID: 19557902

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed only in regenerating islets, but not in normal pancreatic islets, insulinomas or regenerating liver.
  • 数据库链接：

    KEGG: rno:24714

    STRING: 10116.ENSRNOP00000054678

    UniGene: Rn.11332