Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Laforin (Epm2a)

Recombinant Rat Laforin (Epm2a)

  • 货号：
    CSB-YP845997RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP845997RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP845997RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP845997RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP845997RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Epm2a
  • Uniprot No.：
  • 别名：
    Epm2a; Laforin; EC 3.1.3.-; EC 3.1.3.16; EC 3.1.3.48; Glucan phosphatase; Lafora PTPase; LAFPTPase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    FGVVDQPAVA GTRLELLLAG SRPELGRWEP RGAVRLRPAG TAAGAAALAL QEPGLWLAEV ELAPEEEAAD GAEPGRIDTF WYKFLQREPG GELHWEGNGP HHDRCCTYNE NNLVDGVYCL PVGHWIEATG HTNEMKHTTD FYFNIAGHQA MHYSRILPNI WLGSCPRQLE HVTIKLKHEL GITAVMNFQT EWDIIQNSSG CNRYPEPMTP DTMMKLYKEE GLAYIWMPTP DMSTEGRVQM LPQAVCLLHA LLENGHTVYV HCNAGVGRST AAVCGWLHYV IGWSLRKVQY FIMAKRPAVY IDEEALAQAQ QDFFQKFGKV HSSICTL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane.
  • 蛋白家族：
    Protein-tyrosine phosphatase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: rno:114005

    STRING: 10116.ENSRNOP00000058646

    UniGene: Rn.121954