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  4. Recombinant Rat Interleukin-22 receptor subunit alpha-2 (Il22ra2)

Recombinant Rat Interleukin-22 receptor subunit alpha-2 (Il22ra2)

  • 货号：
    CSB-YP756016RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP756016RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP756016RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP756016RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP756016RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il22ra2; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor family type 2; soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-229
  • 氨基酸序列
    T QPAHVSLKPQ KVQFQSRNFH NILHWQPGNS LTSNGSVYFV QYKTYGQGQW KDKNDCWGTT ALFCDLTKET LDPYEPYYGR VMMAWAGSYS EWTRTPRFTP WWETKLDPPV VTITRVNASL RVRLRPPELP HRNQTGKNTS MENYYNLVYR VSIINNSLEK EQKAYEGTQR AVEIQGLTPH CSYCVVAEMY QPMFDRRSPR SKERCVQIP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
  • 基因功能参考文献：
    1. this study shows that rats with genetic IL-22BP deficiency (Il22ra2-/-) display exacerbated psoriasis that is associated with enhanced expression of IL-22-inducible antimicrobial peptides PMID: 28356382
    2. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID: 26329427
    3. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID: 21041731
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 数据库链接：

    KEGG: rno:444986

    STRING: 10116.ENSRNOP00000016354

    UniGene: Rn.13127