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  4. Recombinant Rat Insulin-like growth factor II (Igf2)

Recombinant Rat Insulin-like growth factor II (Igf2)

  • 货号：
    CSB-YP011088RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011088RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011088RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011088RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011088RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Igf2; Igf-2; Insulin-like growth factor II; IGF-II; Multiplication-stimulating activity; MSA; Multiplication-stimulating polypeptide) [Cleaved into: Insulin-like growth factor II; Preptin]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-91
  • 氨基酸序列
    AYRPSE TLCGGELVDT LQFVCSDRGF YFSRPSSRAN RRSRGIVEEC CFRSCDLALL ETYCATPAKS E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
  • 基因功能参考文献：
    1. We aimed to investigate whether TSN protected H9c2 cardiomyocytes from AngII-induced activation of IGF-2R pathway (IGF-2 and IGF-2R )and hypertrophy by mediating through Estrogen receptors PMID: 28812967
    2. Post-weaning high-fat (HF) diet intake resulted in the reduction of small follicles in adulthood, whereas maternal HF diet had long-term deleterious consequences on female offspring steroidogenesis and coincided with alteration of the upregulation of the imprinted gene Igf2 and changes in ovarian circadian rhythms. PMID: 28417351
    3. The results showed that f1 offspring exposed to p,p'-DDE exhibited impaired glucose tolerance, abnormal insulin secretion, beta-cell dysfunction and altered Igf2 and H19 expression induced by Igf2/H19 hypomethylation, which could be transferred to the F3 offspring through the male germ line. PMID: 28867213
    4. The IGF2 was further de-regulated to assess its mechanism in miR-193-5p-downreuglation induced angiogenic regulation. PMID: 28735866
    5. The hypomethylation observed at the H19 DMR corroborates with aberrant expression of Igf2 and H19 imprinted genes in the resorbed embryos sired by ERb agonist-treated males PMID: 28362134
    6. IGF2 expression in the rat brain both in basal condition and following learning predominantly derives from the maternal allele. PMID: 26495851
    7. Ancestral TCDD exposure may promote epigenetic transgenerational alterations of imprinted gene Igf2 in adult somatic tissue. PMID: 26455773
    8. This study suggests that bisphenol A exposure during early life can result in generational transmission of glucose intolerance and beta-cell dysfunction in the offspring through male germ line, which is associated with hypermethylation of Igf2 in islets. PMID: 26276081
    9. Allele-specific and total expression of hippocampal Igf2 is affected by maternal, grandmaternal caloric restriction in a strain and sex-specific manner. PMID: 24845189
    10. IGF-II may therefore contribute to the mechanisms of neuroprotection. PMID: 24667322
    11. We found that paternal folate deficiency induced a decrease in fetal liver folate content, IGF-2 expression, and the percentage of 5-mC in the fetal whole brain. PMID: 23229416
    12. IGF-IR-mediated activation of intracellular signaling may play a critical role during oxidative stress-induced apoptosis in necrotizing enterocolitis. PMID: 22434232
    13. IGF2 may play a role in tooth differentiation. PMID: 21959847
    14. IMP3 as a glioblastoma-specific proproliferative and proinvasive marker acting through IGF-2 resulting in the activation of oncogenic PI3K and MAPK pathways PMID: 21613208
    15. maternal exposure to a low protein diet and folic acid during gestation alters gene expression of Igf2 and H19 in the liver by regulating the DNA methylation of these genes PMID: 20671425
    16. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein beta and is essential for memory consolidation PMID: 21270887
    17. Results indicate that undernutrition alters the timing and intensity of neonatal beta-cell ontogeny, and suggest that pancreatic IGF-2 in undernourished rats may contribute to the partial suppression of the developmental wave of beta-cell apoptosis. PMID: 19648158
    18. Our results show that maternal malnutrition ameliorates beta-cell mass in undernourished goto-kakizaki fetuses and a specific pancreatic IGF-2 increase may be instrumental in this effect. PMID: 19919529
    19. Data provide evidence for the role for estrogen in acquisition of imprint at Igf2/H19 DMR in testis and help in understanding molecular mechanism of environmental estrogens impacting male fertility. PMID: 19683557
    20. Expression of IGF-II in early experimental hepatocellular carcinomas PMID: 12532445
    21. Igf2 protectes theca-interstitial cell cells from apoptosis, reducing DNA fragmentation. PMID: 15833775
    22. IGF-2 expression in amoeboid microglial cells in the developing brain is related to their activation. PMID: 16448778
    23. The increased cardiac IGF-II, IGF-IIR, caspase 9, and cellular apoptosis were also found in hypertensive rats with abdominal aorta ligation. PMID: 16825605
    24. Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of Igf2. PMID: 17393425
    25. IGF2 and IGF1R have roles in beta cell mass anomaly in embryonic pancreas PMID: 17476475
    26. The insulin-like growth factor II expression was found to be predominant in hepatocellular carcinoma and in early preneoplastic lesions. PMID: 17554210
    27. Presence of IGF-II variants, including proIGF-II, IGF-II(1-87), and mature IGF-II, in the rat circulation during postnatal life, challenging current impression that IGF-II is absent from sera of adult rats. PMID: 17628003
    28. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. PMID: 17724018
    29. PCR analysis of Igf2 gene by using of microsatellite D1Mgh22 has shown polymorphism between hereditary hypertriglyceridemic and Lewis rats. PMID: 18418699
    30. Report abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development. PMID: 18693177
    31. A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus. PMID: 18946176
    32. nicotine exposure prevents the decrease of IGF-II processing in the maternal compartment; this may represent a compensatory mechanism allowing the mother to counteract the negative influence of nicotine on fetal growth and development PMID: 19494366
    33. IGF2 overexpression induced a clear protection against IL1B-induced beta-cell apoptosis. PMID: 19592596
    34. dual role of IGF-II in the control of IGF1R dependent cell apoptosis and involved activation of IGF2R signaling PMID: 19764351
    35. The placenta, the primary source of IGF-II synthesis in pregnancy, drives plasma volume expansion, and that IGF-II is among the regulatory factors of the gestational plasma volume increment. PMID: 19776249

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 数据库链接：

    KEGG: rno:24483

    STRING: 10116.ENSRNOP00000047037

    UniGene: Rn.118681