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  4. Recombinant Rat Inhibin beta A chain (Inhba)

Recombinant Rat Inhibin beta A chain (Inhba)

  • 货号：
    CSB-YP011719RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011719RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011719RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011719RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011719RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Inhba; Inhibin beta A chain; Activin beta-A chain
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    309-424
  • 氨基酸序列
    GL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE CGCS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • 基因功能参考文献：
    1. These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance. PMID: 29113826
    2. The activation of JNK and p38 MAPK pathways in OGD-treated PC12 cells was suppressed by exogenous Act A and enhanced by ActRIIA-Ab. Together, our results suggest that Act A/Smads signaling pathway negatively regulates OGD-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. PMID: 27769859
    3. Activin A/Smad 2/3 and activin A/ERK1/2 signaling pathway may be involved in isoflurane induced postconditioning induced neuroprotection. PMID: 27693962
    4. a self-amplifying loop existed in Act A signaling in PC12 cells PMID: 26721511
    5. Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction. PMID: 24299059
    6. These data suggest that activin A produced by interstitial fibroblasts acts as a potent profibrotic factor during renal fibrosis. Blockade of activin A action may be a novel approach for the prevention of renal fibrosis progression. PMID: 24883308
    7. ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion. PMID: 24141247
    8. retinoid signalling can potently suppress activin-induced proliferation by antagonising G1 phase progression and entry into the cell cycle. PMID: 23831638
    9. A stimulatory role of ActA in the primordial to primary and preantral stages of follicle development, suggesting an inhibitory action of activin on oocyte apoptosis. PMID: 22106407
    10. TNFalpha and IL1alpha stimulates activin A secretion and expression in rat Sertoli cells PMID: 21256182
    11. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of MAD homolog 2 (Drosophila) (Smad2) protein, Smad3, and Smad4 in vitro. PMID: 19782349
    12. Activin-A was involved in myocardial ischemia/reperfusion injury. Expression was negatively correlated with suppression of hydroxy free radical and lactate dehydrogenase. PMID: 19292055
    13. Activin beta(A) gene activation is mediated by a calcuim/calmodulin pathway in RBL-2H3 mast cells. PMID: 12681448
    14. The homodimer of activinin/inhibin betaA subunit. particioates in wound healing. In this study we intended to determine its part in gastric ulceration. PMID: 12737440
    15. Activin A produced by ureteric bud is not only an important regulator of ureteric bud branching, but also a differentiation factor for metanephric mesenchyme during kidney development. PMID: 12761253
    16. active inhibin A secretion correlated with development of a luteinized rat ovarian tumor; positive correlation between inhibins and LH suggests that LH may be the main driving force behind tumor production PMID: 12782410
    17. In a rat model of HF, we demonstrated induction of the gene expression of activin betaA after myocardial infarction. PMID: 14993131
    18. high local concentrations of activin A during the period of Sertoli cell proliferation and the onset of spermatogenesis support its proposed role because a modulator of testicular development and function. PMID: 15070852
    19. Activin and BDNF transcriptional activities accurately mark excitatory neurons participating in seizure-induced synaptic alterations and may contribute to the enduring changes that underlie the kindled state. PMID: 15236469
    20. results of this study link overexpression of activin A to glomerular matrix protein expansion in vivo and in vitro, suggesting that activin A acts as pro-fibrotic cytokine in renal disease. PMID: 15673690
    21. Data suggest that betaA- and betaC-activin subunit proteins and follistatin are autocrine growth regulators in regenerating liver and when expressed independently lead to hepatocyte apoptosis or mitosis in a subset of hepatocytes. PMID: 15821113
    22. Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours PMID: 16935389
    23. These results indicate that both Activin-A and -B share the potential to induce neuroprotective activity and thus may have positive impact on aging and neurodegenerative diseases to retard the accelerated rate of neuronal degeneration. PMID: 17680997
    24. Activin-A can regulate myometrial cell functions. PMID: 18239071
    25. Ischemia-reperfusion injury of peripheral nerves caused by various reasons affects the levels of TGF beta1 and activin A but not TGF beta2 PMID: 18597229
    26. Activin betaA subunit, follistatin and follistatin-like 3 are expressed in the endometrium of ovariectomized rats and regulated by estrogen replacement PMID: 18781389
    27. These results indicate that ALK-SMAD3-Dec1 signalling provides an input pathway in the mammalian molecular clock. PMID: 19029909
    28. Activin A is involved in tubulointerstitial fibrosis in diabetic nephropathy by inducing the production of fibronectin through Smad signal pathway. PMID: 19298640
    29. Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo following vascular injury. PMID: 9239411
    30. Activin A regulates tubular cell growth and differentiation by modulating the expression of Pax-2 during regeneration. PMID: 12444203

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    KEGG: rno:29200

    STRING: 10116.ENSRNOP00000019272

    UniGene: Rn.9874