Recombinant Rat Heme oxygenase 1 (Hmox1)

1. HO-1 activation could inhibit cecal ligation and puncture (CLP)-induced lung endoplasmic reticulum stress and attenuate CLP-induced acute lung injury PMID: 30013453
2. the present study revealed that Bone marrow mesenchymal stem cells protected against liver Ischemia/reperfusion (I/R) injury injury via the promotion of HO1mediated autophagy. PMID: 29956785
3. The present study indicates that overexpression of HO-1 in bone marrow-derived mesenchymal stem cells enhances the survival and the renal-epithelial differentiation of bone marrow-derived mesenchymal stem cells in the acute kidney injury microenvironment. PMID: 29749549
4. These finding highlights NOS-dependent modulatory roles for HO. PMID: 29635898
5. Results imply that octreotide-induced autophagy is dependent on heme oxygenase 1 (HO-1) during hepatic ischemia-reperfusion (I/R). PMID: 29385400
6. voluntary physical exercise mitigates impaired spatial memory and neuropathological changes exhibited by the aging sedentary group, via elevated HO-1 activity, contributing to the antioxidant capacity in the aging brain. PMID: 29662895
7. HO-1/BVD/CO pathway activation provides anti-nociceptive and anti-inflammatory effects on the zymosan-induced temporomandibular joint disorders hypernociception in rats PMID: 29362850
8. n-propargyl caffeamide (PACA) attenuated LPS-induced NF-kB activation while activated Nrf2/HO-1 pathway. HO-1 inhibitor SnPP attenuated the effects of PACA on iNOS expression in LPS-challenged macrophages, possibly by regulating the cross-talk between HO-1 and NF-kB pathways. PMID: 29996121
9. Effective inhibition of HO-1 expression may contribute to enhancement in the therapeutic effect of Photodynamic therapy (PDT) using talaporfin sodium against malignant meningioma. PMID: 29743446
10. myricetin treatment significantly increased the activity of Nrf2/HO-1 pathway, strengthening antioxidative stress capacity evidenced by reversed activities of GPx and SOD, and decreased MDA production. PMID: 29147465
11. findings suggested that L-arginine/NO reduces renal dysfunction associated with I/R of the kidney and may act as a trigger to regulate the NF-kappaB, HSP70 and Nrf2/HO-1 signaling cascades. PMID: 28854440
12. autophagy is involved in the protective effects of HO-1/BM-MSCs on the transplanted liver after RSLT. Regulation of autophagy is primarily mediated through the ERK/mTOR signaling pathway. PMID: 28901391
13. This study shows that systemic CO treatment can promote an anxiolytic-like effect and the expression of HO-1 enzymes in locus coeruleus cells. PMID: 28887196
14. Abeta(1-42) is toxic to astrocytes, but induction of HO-1 affords protection against this toxicity due to formation of CO PMID: 28617444
15. heme oxygenase-1-in bone marrow mesenchymal stem cells has an effect on microcirculation and energy metabolism following liver transplantation PMID: 28596681
16. results implied that HO-1 upregulation suppressed oxidative stress induced by LPS, and the possible mechanism could be associated with Mfn1 and the PI3K/Akt pathway. PMID: 27830717
17. Cardioprotective Effect of Selective Estrogen Receptor Modulator Raloxifene Are Mediated by Heme Oxygenase in Estrogen-Deficient Rat PMID: 28770019
18. This study points to the modulatory effect of C. molmol on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, C. molmol might be a promising protective agent against hyperammonemia. PMID: 28744340
19. SERPINB1 decreased inflammation, ameliorated oxidative stress in the lung, and attenuated acute lung injury in rats with orthotopic autologous liver transplantation by activating HO-1 and it does so through STAT3 PMID: 28427999
20. NIC pretreatment effectively inhibit CME-induced myocardial apoptosis and improve cardiac function. The protective effects are mediated through the activation of the Nrf2/HO-1 signaling in cardiomyocytes. PMID: 29412163
21. H2O2 induced expression of HO-1. Exogenous HO-1 reduced phosphorylation of MLK3, MKK7 and JNK3. Consistent with its inhibitory effect on MLK3/MKK7/JNK3 signaling, exogenous HO-1 decreased H2O2-induced neuronal apoptosis and necrosis. It inhibited expression of Cdc42. Down-regulation of MLK3/MKK7/JNK3 signaling might be related to up-regulation of microRNA-137. PMID: 27864650
22. Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver via heme oxygenase-1-mediated autophagy. PMID: 27852058
23. Together with results showing involvement of TTF-1 in the TNF-alpha-induced increase in interleukin 1 beta and monocyte chemotactic protein 1 production, this study suggests that TTF-1 plays an important role in the mouse hypothalamus TNF-alpha-induced inflammatory response for regulating HO-1 gene expression. PMID: 29305861
24. The renoprotection by hemin was accompanied by the reduction of inflammatory/oxidative mediators including, macrophage-inflammatory-protein-1alpha, macrophage-chemoattractant-protein-1 and 8-isoprostane, whereas HO-1, HO-activity and the total-anti-oxidant-capacity increased. PMID: 25460740
25. Alpha-melanocyte-stimulating hormone induces vasodilation and exerts cardioprotection through the heme-oxygenase pathway in rat hearts. PMID: 28195947
26. Since the rat is the preferred laboratory animal in experimental physiology and pathophysiology, the rat model of HO-1 deficiency may provide a novel tool for investigation of the role of this enzyme in renal function and disease. PMID: 27778153
27. Downregulation of histone acetylation can inhibit manganese chloride-induced Nrf2 nuclear translocation and further inhibits the Nrf2/HO-1 pathway in manganese neurotoxicity syndromes. PMID: 29054681
28. Fructose decreases HO-1 expression in maternal liver and placenta. PMID: 27545118
29. Hemoglobin-activated astrocytes acquired resistance to hemin-induced toxicity via Nrf2/HO-1 pathway. This phenomenon can be considered as the adaptive self-defense in the pathological process of intracerebral hemorrhage. PMID: 29074371
30. Biliary tract external drainage BTED protected multiple organs against severe acute pancreatitis related injuries via HO-1 upregulation. PMID: 28209258
31. The expression of Nrf2/HO-1 increased in mesenteric arteries of portal hypertensive rats, which was related to oxidative stress. HO-1was involved in increased portal pressure and anomaly splanchnic hemodynamics in portal hypertensive rats. PMID: 28025064
32. In order to elucidate the possible role of HO-1 in mediating the protective effects of ghrelin, tin protoporphyrin (SnPP) HO-1 blocker was administrated; it significantly attenuated the gastroprotective effect of ghrelin. In conclusion HO-1 activity significantly contributes toward ghrelin-mediated gastroprotection. PMID: 28635609
33. HO-1 is a physiologic regulator of glomerular decay accelerating factor (DAF) and identify hemin analogues as inducers of functional glomerular DAF able to minimize complement component C3 fragment b (C3b) deposition. PMID: 27662796
34. HO-1 Protects against Hypoxia/Reoxygenation-Induced Mitochondrial Dysfunction in H9c2 Cardiomyocytes PMID: 27138700
35. the results of this study suggest that extratumoral HO-1+ macrophages may have an important role in prostate cancer. PMID: 27280718
36. this study shows that overexpression of HO-1 in bone marrow mesenchymal stem cells increased their immunomodulatory effects protected liver allografts PMID: 28069109
37. this experiments shown here indicate that HO-2 and HO-1 are differentially regulated across sexual experience and that the two CO-producing enzymes are expressed in distinct but overlapping populations of cells in medial preoptic area. PMID: 28088559
38. Data show that nonylphenol (NP) increased serum alkaline phosphatase, lead to liver damage and can increase the expression of heme oxygenase-1 (HO1) and growth arrest and DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify the toxic effects on liver through induction of oxidative stress. PMID: 27590577
39. Heme oxygenase 1 induction protects against diabetic nephropathy in streptozotocin-induced diabetic rats. PMID: 28229631
40. remote ischemic preconditioning protects hepatic microcirculation by induction of HO and modulation of cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury PMID: 27672274
41. Heme oxgenase-1 expression in concanavalin A-stimulated T cells that were co-cultured with adipose-derived stem cells revealed a significant increase compared with concanavalin A-stimulated T cells alone. TGF-beta and interleukin-10 increased and interferon-gamma decreased in the adipose-derived stem-cell-co-cultured T-cell group compared with other groups. A heme oxgenase inhibitor protected against these changes. PMID: 27391839
42. HO-1 expression in response to Cd maintains cellular homeostasis during oxidative stress in NRK52E kidney cells PMID: 27658547
43. alpha-Boswellic acid decreases oxidative stress. Nrf2/HO-1 pathway might play a role in the gastroprotective action of alpha-BA in ethanol-induced gastric injury in rats. PMID: 26992040
44. The induced expression of HO-1 by fenofibrate appeared to be essential for mediating the protective effects of fenofibrate, as the inhibition of HO-1 activity significantly diminished the protective effects of fenofibrate against the GM-mediated death of sensory hair cells in cochlea PMID: 28290603
45. Ethylbenzene induced oxidative stress, apoptosis, and up-regulation of HO-1 and Nrf2 in NRK-52E cells. PMID: 26381691
46. HO-1 activity and protein are increased significantly in rats with acute liver injury induced by LPS, suggesting that HO-1 plays an important role in the pathogenesis of acute hepatic damage. PMID: 27432233
47. 18beta-GA has a protective effect on MTX-induced nephrotoxicity with possible mechanisms of attenuating oxidative stress and inflammation through up-regulating the Nrf2/ARE signaling PMID: 27499091
48. Intermittent hypoxia exposure also increased hepatic expression of HO-1 and iron-binding protein ferritin-1 at the late phase, in association with increase in serum iron, bilirubin, and hepatic levels of lipid peroxides, such as 4-hydroxy-2-nonenal (HNE). PMID: 27021659
49. Expression of tumor necrosis factor (TNF)alphainduced protein 8-like 2 (TIPE2), matrix metalloproteinase-9 (MMP-9) and heme oxygenase-1 (HO-1) and mitogen-activated protein kinase (MAPK) signaling was modulated by Xuebijing injection (XBJ). PMID: 27666960
50. rats treated with PAN. CONCLUSION: Depending on the type of injury, HO-1 overexpression in GEC may or may not reduce proteinuria. Reduced macrophage infiltration and preservation of nephrin expression are putative mechanisms underlying the protective effect of HO-1 overexpression following immune injury PMID: 27442135

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KEGG: rno:24451

STRING: 10116.ENSRNOP00000019192

UniGene: Rn.3160