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  4. Recombinant Rat Granulins (Grn)

Recombinant Rat Granulins (Grn)

  • 货号：
    CSB-YP009939RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009939RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009939RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009939RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009939RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    GrnProgranulin; PGRN; Acrogranin; Epithelin precursor; Granulin precursor; Proepithelin; PEPI) [Cleaved into: Paragranulin; Granulin-1; Granulin G); Granulin-2; Granulin F); Granulin-3; Epithelin-2; Granulin B); Granulin-4; Epithelin-1; Granulin A); Granulin-5; Granulin C); Granulin-6; Granulin D); Granulin-7; Granulin E)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-588
  • 氨基酸序列
    TQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP IITSRRLDGS CQIRDHCPDG YSCLLTVSGT SSCCPFSEGV SCDDGQHCCP RGFHCSADGK SCSQISDSLL GAVQCPGSQF ECPDSATCCI MIDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCISP TGTHPLLKKF PAQRTNRAVA SFSVVCPDAK TQCPDDSTCC ELPTGKYGCC PMPNAICCSD HLHCCPQDTV CDLIQSKCIS KDYTTDLMTK LPGYPVNEVK CDLEVSCPDG YTCCRLNTGA WGCCPFTKAV CCEDHIHCCP AGFQCHTETG TCELGVLQVP WMKKVTASLS LPDPQILKND VPCDDFSSCP SNNTCCRLSS GDWGCCPMPE AVCCLDHQHC CPQGFKCMDE GYCQKGDRMV AGLEKMPVRQ TTLLQHGDIG CDQHTSCPVG QTCCPSLKGS WACCQLPHAV CCEDRQHCCP AGYTCNVKAR TCEKDAGSVQ PSMDLTFGSK VGNVECGAGH FCHDNQSCCK DSQGGWACCP YVKGVCCRDG RHCCPIGFHC SAKGTKCLRK KTPRWDILLR DPAPRPLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity.; Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8.; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.
  • 基因功能参考文献：
    1. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. PMID: 28609022
    2. Activity-dependent secretion of pro-granulin can regulate synapse number and structure. PMID: 24046442
    3. Proepithelin stimulates growth plate chondrogenesis via nuclear factor-kappaB-p65-dependent mechanisms. PMID: 21566130
    4. inappropriate expression of grn and/or p130 genes in the brains of male and female neonatal rats by perinatal exposure to phthalate/adipate esters may exert permanent effects on the hypothalamus, thereby decreasing sexual behavior after maturation PMID: 16493179
    5. estrogen induces granulin gene expression in the hippocampus and that the product of this gene is involved in the mitogenic effects of estrogen in the dentate gyrus, although the responses to estrogen decline with age. PMID: 17179653

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  • 亚细胞定位：
    Secreted. Lysosome.
  • 蛋白家族：
    Granulin family
  • 组织特异性：
    Ubiquitous; most abundant in the spleen and several tissues of endocrine significance.
  • 数据库链接：

    KEGG: rno:29143

    STRING: 10116.ENSRNOP00000028557

    UniGene: Rn.5820