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  4. Recombinant Rat Gastrin-releasing peptide (Grp)

Recombinant Rat Gastrin-releasing peptide (Grp)

  • 货号：
    CSB-YP009940RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009940RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009940RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009940RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009940RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grp
  • Uniprot No.：
  • 别名：
    GrpGastrin-releasing peptide; GRP) [Cleaved into: Neuromedin-C; GRP-10)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    24-52
  • 氨基酸序列
    APVSTGA GGGTVLAKMY PRGSHWAVGH LM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake.
  • 基因功能参考文献：
    1. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. PMID: 26860455
    2. feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat PMID: 24993846
    3. all forms of GRP reduce food intake in obese and lean adult Zucker rats similar to Bn in weanling rats. PMID: 24874706
    4. The site of action of rat gastrin releasing peptide, in regulation of meal size and intermeal interval, is most likely the stomach and/or the duodenum. PMID: 24556509
    5. Gastrin-releasing peptide terminals were found in spinal dorsal horn and trigeminal ganglion. PMID: 24254931
    6. GRP regulation of meal size and intermeal interval occurs at different sites in the rat. PMID: 24291388
    7. Gastrin-releasing peptide acts via postsynaptic bombesin type 2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons PMID: 23359674
    8. reduction of meal size and prolongation of intermeal interval (IMI) by GRP-29 require vagal and splanchnic nerves, and the duodenum is the major conduit that communicates prolongation of IMI by GRP-29 with the brain PMID: 22210008
    9. With increasing levels of fear, levels of gastrin-releasing peptide (Grp) are increased in medial prefrontal cortex and basolateral amygdala. PMID: 20974156
    10. GRP-29 and GRP-27 reduced the size of the first meal, prolonged intermeal interval and increased satiety ratio, but GRP-10 failed to exhibit similar feeding responses. The data support a role for GRP-29 in the short-term regulation of food intake. PMID: 21055429
    11. These high-voltage electron microscopy findings provide an ultrastructural basis for understanding how the spinal GRP system regulates male sexual behavior. PMID: 19864484
    12. Data suggest that GRP, by acting on GRP receptors but not via CRF receptors, increases 5-HT neuronal activity in the paraventricular nucleus. PMID: 12138009
    13. GRP in the central part of the amygdala inhibits feeding, may decrease the efficiency of eating, and may act as a satiety signal. PMID: 12419521
    14. the increase in gastrin relesing peptide synthesis in the neurosecretory structures of the hypothalamus shoud be regarded as a compensatory reaction in diabetes PMID: 12469881
    15. GRP mRNA was detected in rat kidney from embryonic day 19 to postnatal day 30 by RT-PCR PMID: 15140764
    16. Data suggest that GRP does affect the stress response. GRP alterations selectively affected fear-related responses. PMID: 17335915
    17. Food deprivation and stimulation of the melanocortin system produce opposing changes in GRP gene expression in the PVN; GRP-containing neurons in the PVN may be part of the hypothalamic signaling pathway controlling food intake and energy balance. PMID: 18818295
    18. the spinal GRP system appears to be a stress-vulnerable center for male reproductive functions PMID: 19169356
    19. Results suggest that androgen signaling plays a pivotal role in the regulation of GRP expression in male lumbar spinal cord. PMID: 19359382

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
  • 蛋白家族：
    Bombesin/neuromedin-B/ranatensin family
  • 数据库链接：

    KEGG: rno:171101

    STRING: 10116.ENSRNOP00000022845

    UniGene: Rn.10930