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  4. Recombinant Rat GTP-binding protein REM 2 (Rem2)

Recombinant Rat GTP-binding protein REM 2 (Rem2)

  • 货号：
    CSB-YP893881RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP893881RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP893881RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP893881RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP893881RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rem2
  • Uniprot No.：
  • 别名：
    Rem2; GTP-binding protein REM 2; Rad and Gem-like GTP-binding protein 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    MHTDLDTDMD ADTETVALCS SSSRQASPSG TPTPEADTTL LKQKPEKLLA ELDRGGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASSSGSSD SLGSGEAALA QKDGVFKVML LGESGVGKST LAGTFGGLQG DNAHEMENSE DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD RRSFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
  • 基因功能参考文献：
    1. When rats become maternal, they increase the expression of Rem2 in the medial preoptic area which inhibits dendritic complexity and associates with an enhancement of maternal responsiveness. PMID: 28259675
    2. Rem2 is regulated at the transcriptional level by calcium influx and inhibits dendritic arborization in cultured rat cortical neurons PMID: 24403140
    3. structure of the Rem2 G domain bound to GDP is reported here in a monoclinic crystal form at 2.66 A resolution PMID: 22684057
    4. molecular mechanisms by which Rem2 knockdown affected synaptogenesis and Ca(2) homeostasis in cultured rat hippocampal neurons PMID: 21980534
    5. our results suggest that Rem2 regulates dendritic branching and synapse development PMID: 21485012
    6. Rem2 localizes to the plasma membrane via a C-terminal motif and interacts with calcium channel beta subunits in the preassembled N-type channel, thereby forming a nonconducting species. PMID: 16237180
    7. Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus. PMID: 18068949

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  • 亚细胞定位：
    Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 组织特异性：
    Expressed in brain and kidney.
  • 数据库链接：

    KEGG: rno:64626

    STRING: 10116.ENSRNOP00000016020

    UniGene: Rn.48804