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  4. Recombinant Rat Four and a half LIM domains protein 1 (Fhl1)

Recombinant Rat Four and a half LIM domains protein 1 (Fhl1)

  • 货号：
    CSB-YP894826RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP894826RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP894826RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP894826RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP894826RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fhl1Four and a half LIM domains protein 1; FHL-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-280
  • 氨基酸序列
    SEKFDCHYC RDPLQGKKYV QKDGRHCCLK CFDKFCANTC VECRKPISAD AKEVHYKNRY WHDTCFRCAK CLHPLASETF VSKDGKILCN KCATREDSPR CKGCFKAIVA GDQNVEYKGT IWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHAECFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG FGKGSSVVAY EGQSWHDYCF HCKKCSVNLA NKRFVFHNEQ VYCPDCAKKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.
  • 基因功能参考文献：
    1. FHL1 may be involved in excessive cell proliferation and may represent a potential therapeutic target for pulmonary hypertension. PMID: 25975448
    2. FHL1 exists as part of a complex, which binds gamma-actin and non-muscle myosin IIB PMID: 24265776
    3. Hypoxia-induced downregulation of miR-206 promotes pulmonary hypertension by targeting the HIF-1alpha/Fhl-1 pathway in pulmonary artery smooth muscle cells. PMID: 23628900
    4. FHL1 knockdown significantly inhibited the proliferation of rat aortic smooth muscle cells but exerted no obvious effect on cell apoptosis. PMID: 21126853
    5. These data indicate that estradiol down-regulates Fhl1 expression through its binding to the ERbeta. PMID: 20149813
    6. Over-production of SLIM1 in the cells resulted in a change in the cell-shape into a spindle-like form. PMID: 17161435
    7. Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading. PMID: 18756007

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: rno:25177

    STRING: 10116.ENSRNOP00000049677

    UniGene: Rn.54261