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  4. Recombinant Rat FERM domain-containing protein 8 (Frmd8)

Recombinant Rat FERM domain-containing protein 8 (Frmd8)

  • 中文名称：
    大鼠Frmd8重组蛋白
  • 货号：
    CSB-YP736004RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Frmd8重组蛋白
  • 货号：
    CSB-EP736004RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Frmd8重组蛋白
  • 货号：
    CSB-EP736004RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Frmd8重组蛋白
  • 货号：
    CSB-BP736004RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Frmd8重组蛋白
  • 货号：
    CSB-MP736004RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Frmd8
  • Uniprot No.：
  • 别名：
    Frmd8FERM domain-containing protein 8
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-466
  • 氨基酸序列
    MEGAEGNAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLS SISAHELHRA VREVLQLPDM ALEAFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTD ASDDDIAMDE PSLQFRRNVF FPKRRELQVH DEEVLRLLYE EAKGNVLTAR YPCDLEDCEV LGGLVCRVQL GPYQPGQPAA CTVREKLDSF LPAHLCKRGH GLFAAFRGRG AKTGPCEQGL LNAYRQVKEM AGGDSERETT LGSHYRAYLL KCHELPFYGC AFFHGEVDKP TQGFLHRGGR KPVTVAISLE GVHVIDNREK HVLLGLRFQE LSWDHTSPEE EEPVLWLEFD GDSEGTPVNK LLRIYSKQAE LMSVLIEYCI ELSQAAEPAL PQESASGPQE APSPSSAPTQ RPKLRRQGSV VCSRIQHLST IDYVEDGSGI KRVKPKRTTS FFSRQLSSSH GSYTVVQPND NSPEQG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane.
  • 数据库链接：

    KEGG: rno:309172

    STRING: 10116.ENSRNOP00000028331

    UniGene: Rn.1260