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  4. Recombinant Rat Dystrophin (Dmd), partial

Recombinant Rat Dystrophin (Dmd), partial

  • 货号：
    CSB-YP006963RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006963RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006963RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006963RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    DmdDystrophin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
  • 基因功能参考文献：
    1. that decreased expression of dystrophin and increased expression of calpains are coincident and could work as possible therapeutic targets to prevent heart failure as a consequence of cardiac hypertrophy PMID: 29267303
    2. results show that dystrophin 71d, dystrophin 71f and dystrophin-associated protein integrate protein complexes, and both complexes were associated to nuclear speckles structures. PMID: 26378780
    3. Dp40 can interact with beta-dystroglycan as observed by co-localization assays and the co-localization was reduced with Dp40 mutants. PMID: 26004254
    4. Hypoxia-induced muscle damage is not accompanied by the loss of dystrophin and desmin. PMID: 20717635
    5. Dp71 is a component of the mitotic spindle and cytokinesis multi-protein apparatuses that might modulate the cell division cycle by affecting lamin B1 and beta-dystroglycan levels. PMID: 21886794
    6. This study found that cells stably expressing Dp71Delta(78-79) (PC12-C11) differentiate more efficiently than non-transfected cells. PMID: 21668890
    7. we established by immunoprecipitation assays that Dp71 and the dystrophin-associated proteins form a dystrophin-associated protein complex in the cell nucleus. PMID: 19784870
    8. dysfunction of dystrophin may result in endothelial and astroglial damage leading to vasogenic edema that is involved in pathogenesis of epileptogenesis PMID: 21029730
    9. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. PMID: 21164104
    10. results reveal a crucial role of MMP-mediated beta-DG cleavage in autoimmune neuritis, such as Guillain-Barre' syndrome, and bring insights into therapeutic strategies for autoimmune diseases. PMID: 20097170
    11. Components of dystrophin-dystroglycan complex were also distributed along the blood vessels of the pineal gland PMID: 19924636
    12. the distribution of dystrophin in series-fibred muscles suggests they are involved in transmission of tension from PMID: 12037582
    13. expression of dystrophin during skeletal muscle regeneration PMID: 12086334
    14. During a cycle of regeneration in tibialis anterior muscle following myonecrosis, dystrophin is found to be weakly labeled at the sarcolemma on day 5 and moderately stained on day 7. PMID: 12416719
    15. Loss of sarcolemmal dystrophin may be involved in the mechanism of contractile force-induced reperfusion injury. PMID: 12890920
    16. Results present immunocytochemical localization of beta-dystroglycan, the central member of the dystrophin glycoprotein complex, and show that beta-dystroglycan and utrophin are colocalized in clusters in all parts of Muller cells. PMID: 14711029
    17. Cardioprotection conferred by ischemic preconditioning may be enhanced by temporary blockade of contractile activity until restoration of membrane dystrophin during reperfusion. PMID: 15001448
    18. Dmd deficient PC12 cells generated by addition of antisense-Dp71 cells exhibited a marked suppression of neurite outgrowth. Early responses were normal, late responses were disturbed. PMID: 15149856
    19. Dp71 protein contributes to the proper functioning of the cerebrospinal fluid and blood-brain barriers PMID: 15501597
    20. These data support the notion of a physiological role of Dp71f distinct from other dystrophin isoforms present in the central nervous system. PMID: 16841465
    21. evaluation of the effect of repeated bouts of exercise on on skeletal muscle titin, desmin & dystrophin; desmin and dystrophin mRNA levels were increased after the first and fifth sessions PMID: 17436058
    22. Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex. PMID: 18677563
    23. Dp71d is a dynamic component of nuclear matrix that might participate in the nuclear modeling occurring during neuronal differentiation. PMID: 18687308
    24. Findings demonstrate the interdependence between laminin binding to dystroglycan and GM1-containing lipid raft reorganization and provide novel insight into the dystrophin complex regulation of AQP4 polarization in astrocytes. PMID: 19451651
    25. dystrophin Dp71f is important for the function that the beta1-integrin complex has during neurite outgrowth PMID: 19681445

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  • 亚细胞定位：
    Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Strongly expressed in skeletal muscle and weak expression observed in newborn brain which increases in adult brain.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000029969

    UniGene: Rn.10307