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  4. Recombinant Rat Dexamethasone-induced Ras-related protein 1 (Rasd1)

Recombinant Rat Dexamethasone-induced Ras-related protein 1 (Rasd1)

  • 中文名称：
    大鼠Rasd1重组蛋白
  • 货号：
    CSB-YP888340RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rasd1重组蛋白
  • 货号：
    CSB-EP888340RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rasd1重组蛋白
  • 货号：
    CSB-EP888340RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rasd1重组蛋白
  • 货号：
    CSB-BP888340RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rasd1重组蛋白
  • 货号：
    CSB-MP888340RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rasd1
  • Uniprot No.：
  • 别名：
    Rasd1; Dexras1; Dexamethasone-induced Ras-related protein 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-277
  • 氨基酸序列
    MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE DAYTPTIEDF HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI LVFSLDNRDS FEEVQRLKQQ ILDTKSCLKN KTKENVDVPL VICGNKGDRD FYREVEQREI EQLVGDDPQR CAYFEISAKK NSSLDQMFRA LFAMAKLPSE MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGDHGD AFGILAPFAR RPSVHSDLMY IREKTSVSSQ AKDKERC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65.
  • 基因功能参考文献：
    1. Rasd1 is an estrogen-responsive immediate early gene and modulates E2 induction of at least several late genes in anterior pituitary cells. PMID: 28835591
    2. The Dexras1 protein is expressed predominantly in the dorsomedial part of thesuprachiasmatic nucleus and the light pulse has only a limited effect on its expression PMID: 26785766
    3. two mechanisms of Rasd1 induction in the hypothalamus, were identified. PMID: 26739966
    4. RASD1 is downregulated by calycosin in cerebral ischemia/reperfusion injury and provides a protective effect. PMID: 24548484
    5. Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart. PMID: 22408026
    6. Data suggest that Dexras 1 is involved in CNS cell death and demyelination in EAE through nitric oxide signaling by binding to nNOS and CAPON. PMID: 20084551
    7. Dexras1 is involved in various pathological conditions including nerve regeneration, neuron loss or survival and even pain processes via regulating nNOS activity or through the downstream targets of Dexras1. PMID: 17768032
    8. Transient high expression of Dexras1 which localized in apoptotic neurons and pathological oligodendrocytes after spinal cord transection. PMID: 18219571

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族：
    Small GTPase superfamily, RasD family
  • 组织特异性：
    Prominently found in brain at both mRNA and protein levels. Moderate expression in testis and lung. Slightly expressed in heart, spleen, skeletal muscle, liver and kidney.
  • 数据库链接：

    KEGG: rno:64455

    STRING: 10116.ENSRNOP00000004475

    UniGene: Rn.54720