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  4. Recombinant Rat Death ligand signal enhancer (Dele)

Recombinant Rat Death ligand signal enhancer (Dele)

  • 货号：
    CSB-YP012168RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012168RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012168RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012168RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012168RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dele
  • Uniprot No.：
  • 别名：
    Dele1; Dele; DAP3-binding cell death enhancer 1; Death ligand signal enhancer
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    102-509
  • 氨基酸序列
    IHFHAPLVA GPQSAERCSW HSPLYRFLSS SWWHPHSSLR RYVLPSPDCP APRNTGLREP RLGQEEPAAR SQGLPSDSSL KPGLLNLPEE EPSDFGFLNA SRDFTSQAKA AEAGPPGGKN EQDKPKALPL EEAVTSIQQL FQLSVAIAFN FLGTENIKTG DYTAAFSYFQ KAADRGYSKA QYNVGLCLEH GRGTPRDLSK AVLFYHLAAV QGHSLAQYRY ARCLLQSPGS MSDPERQRAV SLLKQAADSG LTEAQAFLGV LFTKEPHLDE QKAVKYFWLA ASNGDSQSRF HLGICYEKGL GVQRNLGEAV KCYQKSAAMG NEPAQERLRT LFNVEAAGPS HLAIGLKSFS SPSLCSLNTF LAGASGLPHA SSTGNLGLLC RSGHLGTSHG APSRAMPSLE RSLVRLGFG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key activator of the integrated stress response (ISR) following mitochondrial stress. In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.; Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR.
  • 基因功能参考文献：
    1. Functionally characterizes the human homolog as a DAP3-binding protein involved in apoptosis mediated by death receptors. PMID: 20563667
  • 亚细胞定位：
    [DAP3-binding cell death enhancer 1]: Mitochondrion. Mitochondrion inner membrane.; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol.
  • 数据库链接：

    KEGG: rno:307480

    STRING: 10116.ENSRNOP00000026273

    UniGene: Rn.12899