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  4. Recombinant Rat Cyclin-dependent kinase 5 activator 1 (Cdk5r1)

Recombinant Rat Cyclin-dependent kinase 5 activator 1 (Cdk5r1)

  • 货号：
    CSB-YP005069RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005069RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005069RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005069RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005069RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdk5r1
  • Uniprot No.：
  • 别名：
    Cdk5r1; Cdk5r; Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1; p35; p35); Cyclin-dependent kinase 5 activator 1; p25; p25; Tau protein kinase II 23 kDa subunit; p23)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-307
  • 氨基酸序列
    GTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA KKKNSKKAQP NSSYQSNIAH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG VSSSVKKAPH PAITSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR LLLGLDR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
  • 基因功能参考文献：
    1. luciferase reporter assay, and rescue experiments suggested that miR-sc4 executed its effect through directly targeting cyclin-dependent kinase 5 activator 1 (Cdk5r1) PMID: 29388152
    2. Overexpression of Cdk5r1 is sufficient to induce pancreatic -cell proliferation. PMID: 26788519
    3. Our findings suggest that p35/Rac1 signaling is critical in the CDK5 silencing-induced neuroprotection against glutamate neurotoxicity PMID: 25864429
    4. Cdk5, p35 and p53 genes may be involved in the process of As2O3-induced neural cell apoptosis. PMID: 22801079
    5. Elevation of NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptotic death in rats with experimental glaucoma, which could be effectively ameliorated by inhibiting Cdk5/p35. PMID: 21554958
    6. 2,5-hexanedione can induce significant changes of CDK5 and its activators p35 in nerve tissues. PMID: 18771616
    7. A novel mechanism for serotonin stimulation of hepatic glycogenesis involving cdk5. PMID: 22106156
    8. Data suggest that transient upregulation of p25 may regulate activity of cdk5 in phosphorylating particular substrates, such as Pak1, implicated in the adaptive changes associated with behavioral sensitization to psychostimulants. PMID: 18991853
    9. Change of Cdk5/p35 expression in the hippocampus may play a role in epileptogenesis by influencing the process of mossy fiber sprouting. PMID: 19141975
    10. recombinant gene expression in PC12 cells increases neurosecretion PMID: 20033852
    11. X-ray exposure activates Cdk5 by increasing the p35 and p25 expressions in rat hippocampal neurons. PMID: 19304511
    12. PKCdelta may promote cortical radial migration through maintaining the proper level of p35 in newborn neurons. PMID: 19965374
    13. findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity PMID: 12084709
    14. Data show that phosphorylation of the cdk5 activator p35 influences the proteasome-mediated degradation of p35 and calpain-mediated cleavage of p35 to p25. PMID: 12393264
    15. Regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation in the developing brain. PMID: 12598607
    16. Expression of p35 and CDK5 in insulin-producing beta-cellsis new signaling pathway controlled by glucose, and its functional role may comprise regulation of various biological processes in beta-cells, such as expression of the insulin gene. PMID: 14976144
    17. Effect of the administration at physiologic doses of il-6 to hippocampal neurons, on the protein kinase pathways as well as on the tau phosphorylation patterns and increases cdk5 activity. PMID: 15051507
    18. We have delineated the functional consequence of this cross talk and found that the cdk5 mediated inhibition of MEK1 results in apoptosis. PMID: 17498664
    19. Data demonstrate that a decrease in the level of Egr-1, one of the targets for MAPK, by Tat has a negative impact on the level of p35 expression in NGF-treated neural cells. PMID: 18247371
    20. a role for Cdk5-p35 as a survival factor in countering MPP+-induced neuronal cell death. PMID: 19638632

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  • 亚细胞定位：
    [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection.; [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus. Cytoplasm, perinuclear region. Perikaryon.
  • 蛋白家族：
    Cyclin-dependent kinase 5 activator family
  • 组织特异性：
    Brain and neuron specific.
  • 数据库链接：

    KEGG: rno:116671

    STRING: 10116.ENSRNOP00000062473

    UniGene: Rn.11213