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  4. Recombinant Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap)

Recombinant Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap)

  • 货号：
    CSB-YP015942RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015942RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015942RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015942RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015942RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nos1ap
  • Uniprot No.：
  • 别名：
    Nos1ap; CaponCarboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-503
  • 氨基酸序列
    MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI SFEAKYVGSL DVPRPNSRVE IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK KKEWTWDESK MLVMQDPIYR IFYVSHDSQD LKIFSYIARD GASNIFRCNV FKSKKKSQAM RIVRTVGQAF EVCHKLSLQH TQQNADGQED GESERNSDGS GDPGRQLTGA ERVSTATAEE TDIDAVEVPL PGNDILEFSR GVTDLDAIGK DGGSHIDTTV SPHPQEPMLA ASPRMLLPSS SSSKPPGLGT GTPLSTHHQM QLLQQLLQQQ QQQTQVAVAQ VHLLKDQLAA EAAARLEAQA RVHQLLLQNK DMLQHISLLV KQVQELELKL SGQSTMGSQD SLLEITFRSG ALPVLCESTT PKPEDLHSPL LGAGLADFAH PVGSPLGRRD CLVKLECFRF LPAEDNQPMA QGEPLLGGLE LIKFRESGIA SEYESNTDES EERDSWSQEE LPRLLNVLQR QELGDSLDDE IAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
  • 基因功能参考文献：
    1. This study showed that critical role for the schizophrenia-associated gene NOS1AP in cortical patterning and neuron migration. PMID: 25542305
    2. CAPON modulates neuronal calcium during dysautonomia in hypertension. PMID: 25916729
    3. nNOS and CAPON co-localize in the pre-sympathetic autonomic neurons in the paraventricular nucleus and their expression is reciprocally regulated in congestive heart failure via angiotensin II. PMID: 21831995
    4. CAPON might play a proactive role in the process of inflammation by transferring from cytoplasm to the nucleus and through the NMDA-nNOS signal pathway PMID: 20962540
    5. NOS1AP plays an important role in the mammalian synapse. PMID: 20357130
    6. CAPON may be involved in various pathological conditions including nerve regeneration, neuron loss or survival and even pain process via regulating the nNOS activity or through the downstream targets of Dexras1. PMID: 17768032
    7. Data show that mRNA and protein for CAPON increased at 2 h after spinal cord injury and peaked at 8 h, gradually recovered to the baseline level at 14 days, and expression of nNOS mRNA and protein was similar to that of CAPON. PMID: 18074109
    8. These data suggest that CAPON and all these three isoforms of NOS might be involved in muscle regeneration after nerve injury. PMID: 18157660

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  • 组织特异性：
    Brain-specific. Highly expressed in accessory olfactory bulb, caudate-putamen, cerebellum, cerebral cortex, dentate gyrus of the hyppocampus, islands of Calleja, olfactory bulb and supraoptic nucleus.
  • 数据库链接：

    KEGG: rno:192363

    STRING: 10116.ENSRNOP00000038197

    UniGene: Rn.9903