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  4. Recombinant Rat Calsenilin (Kcnip3)

Recombinant Rat Calsenilin (Kcnip3)

  • 货号：
    CSB-YP884953RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP884953RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP884953RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP884953RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP884953RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnip3
  • Uniprot No.：
  • 别名：
    Kcnip3; Csen; Dream; Kchip3Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-256
  • 氨基酸序列
    MQRTKEAMKA SDGSLLGDPG RIPLSKREGI KWQRPRFTRQ ALMRCCLIKW ILSSAAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYSQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PLEHVERFFQ KMDRNQDGVV TIDEFLETCQ KDENIMSSMQ LFENVI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.
  • 基因功能参考文献：
    1. DREAM expression and REM sleep deprivation, as well as sleep recovery, are linked which may indicate potential involvement of DREAM in REM sleep-induced changes in gene expression, specifically in nociceptive processing. PMID: 25218926
    2. This study demonistrared that the expression and function of KCHIP3 channels in neurons of the rat bed nucleus of the stria terminalis. PMID: 24037673
    3. The expression of calsenilin was found to be increased in brain following experimental ischemic stroke. PMID: 23211047
    4. expression of DREAM was increased in the spinal cord after formalin-induced pain; nitric oxide may play an important role in the DREAM pathway modulation of inflammatory pain PMID: 22814938
    5. This study demonstrated that the KCNIP proteins localize differently when over-expressed in primary cortical neurons. PMID: 22612322
    6. these data suggest an altered expression and function of KChIP3 after streptozotocin induced hyperglycemia that might help explain some pathological alterations in early diabetic retinopathy. PMID: 22277672
    7. In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c). PMID: 21486818
    8. Sumoylation regulates the nuclear localization of DREAM in differentiated neurons. PMID: 21070824
    9. Data suggest that upregulation of DREAM mRNA and protein expression in the nuclear compartment probably has functional consequences other than just the repression of prodynorphin gene. PMID: 21188515
    10. Induction of KChIP3 and functional changes of voltage-gated KV4 channels in Muller cells could exert a physiological role in the onset of diabetic retinopathy. PMID: 21147063
    11. Findings of DREAM expression in the pituitary in a manner specific to pituitary endocrine cell type raises the possibility that this protein may play a role in determining specific pituitary cell function.[DREAM protein] PMID: 12409095
    12. KChIP3 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability. PMID: 15356203
    13. Mutated form of DREAM unable to bind Ca(2+) interferes with thyroid cell proliferation. PMID: 15777797
    14. Glutamate caused nuclear export of DREAM in astrocytes, and transfection of astrocytes with a mutant variant of DREAM that constitutively binds DNA inhibited glutamate-induced c-Fos expression. PMID: 17120244
    15. DREAM might have other roles in pain modulation in spinal cord in addition to its well-known role as a transcriptional repressor. PMID: 17562172
    16. These findings support the notion that the NMDA receptor-dependent modulation of DREAM activity could play a role in relevant physiological processes ranging from retinal response to injury to differentiation capacity of retinal progenitor cells. PMID: 18191896
    17. These results suggest the role of DREAM in the dorsal horn in regulation of PPD gene expression by EAS is frequency dependent, & DREAM may exert different roles in different frequency electroacupuncture under physiological & inflammatory conditions. PMID: 18404375

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus.
  • 蛋白家族：
    Recoverin family
  • 组织特异性：
    Detected in brain cortex, thalamus, dentate gyrus and cerebellum (at protein level). Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells.
  • 数据库链接：

    KEGG: rno:65199

    STRING: 10116.ENSRNOP00000047927

    UniGene: Rn.74239