Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Calpain-10 (Capn10)

Recombinant Rat Calpain-10 (Capn10)

  • 货号：
    CSB-YP884151RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP884151RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP884151RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP884151RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP884151RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Capn10
  • Uniprot No.：
  • 别名：
    Capn10; Calpain-10; EC 3.4.22.-; Calcium-activated neutral proteinase 10; CANP 10
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-666
  • 氨基酸序列
    MRAVRAETRA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQDIC ATPQLFPDNP WEGQVKQGLL GDCWFLCACA ALQKSRHLLD QVFPPGQPGW SDQEYQGFFT CRIWQFGHWE EVTIDDRLPC LAGRLCFSRC QREDVFWLPL LEKAYAKVHG SYEHLWAGQV ADALVDLTGS LAERWSLKDI RKASGQQDRP SGGEHRACQQ LLRLKDQCLL SCSVLSPRAG ARELGEFHAF IISDLQELRS QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL YTEKVLCHTR ALPGAWVTGQ SAGGCRNNSC FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS PAPVNLPGKD YQAVGLHIWK VEKRKISLPR VLSAPPVAGT ACHAYDREIH LRCELSPGYY LAVPSTFLKD VPGQFLLRVF STGKISLSAV RLATKGASPG AALPAGEWET VQLQGSWRAG QTAGGSRNFA SYPCNPCLPF SVPEGAGPRY IRITLQQHCR LSDSQLHPIG FHVFQVPADG EKQDACSLLL QEPLLSCVPH CYAQEVSRLC LLSAGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM LGQLLQEVSF MAVMKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
  • 基因功能参考文献：
    1. diabetes-induced renal mitochondrial dysfunction and renal injury may directly result from the loss of renal calpain 10 PMID: 22568896
    2. Calpain 10 (CAPN10) is reported linked with type 2 diabetes in certain human populations... "Levels of mRNA for type 2 diabetes-related genes such as ...CPN10 were quantified in WBC...in OLETF rats... known to initiate type 2 diabetes at 18 weeks..." PMID: 14646187
    3. 195 gly-ser SNP might be associated with susceptibility to type 2 diabetes mellitus PMID: 14658759
    4. Data show that calpain 10 is a mitochondrially targeted and is a mediator of mitochondrial dysfunction through the cleavage of Complex I subunits and activation of the mitochondrial permeability transition. PMID: 16790502
    5. Finally, we identified a 54 kDa isoform as the major CAPN10 isoform that associates with the actin cytoskeleton. PMID: 17150188
    6. These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice. PMID: 18054326
    7. Calpain 10 levels decreased in the kidney, but not in the liver, with age, and this decrease was attenuated with caloric restriction. PMID: 19144693

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase C2 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: rno:63834

    STRING: 10116.ENSRNOP00000067567

    UniGene: Rn.176334