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  4. Recombinant Rat Bcl-2-like protein 11 (Bcl2l11)

Recombinant Rat Bcl-2-like protein 11 (Bcl2l11)

  • 货号：
    CSB-YP002615RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002615RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002615RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002615RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002615RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Bcl2l11; Bim; BodBcl-2-like protein 11; Bcl2-L-11; Bcl-2-related ovarian death protein; Bcl2-interacting mediator of cell death
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-196
  • 氨基酸序列
    MAKQPSDVNS ECDREGGQLQ PAERPPQLRP GAPTSLQTES QGNPDGEGDR CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL RRIGDEFNET YTRRAFANDY REAEDHPQMV ILQLLRFIFR LVWRRH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Induces apoptosis and anoikis.
  • 基因功能参考文献：
    1. miR-181c could promote the cell viability and inhibit the apoptosis of PC12 cells induced by MPP (+) by downregulating BCL2L11, which may play a protective role. PMID: 28770951
    2. HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis. PMID: 29048431
    3. The results of this study show that CaMKII inhibition transcriptionally upregulates Bim expression to promote neuronal apoptosis. PMID: 27483389
    4. the loss of GCN5 activity and the induction of Egr-1, E2F1 and Bim are involved in the early brain injury (EBI) following subarachnoid haemorrhage (SAH) in rats. PMID: 28125090
    5. TUG1 could directly interact with miR-9 and down-regulating miR-9 could efficiently reverse the function of TUG1 on the Bcl2l11 expression. These result sheds light on the role of LncRNA TUG1 as a miRNA sponge for ischemic stroke, possibly providing a new therapeutic target in stroke. PMID: 28202414
    6. miR-19a protected cardiomyocytes against hypoxia-induced lethality at least in part via Bim suppression and subsequent autophagy activation. PMID: 27220268
    7. the JNK/FOXO3a/Bim pathway is involved in neuronal apoptosis in the developing rat brain after hypoxic-ischemia PMID: 26171786
    8. Individual inhibition of CHOP, BIM, or BID protected against autophagy and cell death PMID: 25772147
    9. Puma is activated by both p53 and PI3K/Akt/FoxO3a pathways and cooperates with Bim to induce neuron death in response to Abeta(1-42) PMID: 24567336
    10. Results revealed regulative role of ERK5/Bim pathway in hypothermal stimulation-induced injury or apoptosis of cardiomyocytes. PMID: 23896225
    11. Bim has a key role for endoplasmic reticulum stress plus IL-1beta-induced apoptosis in primary beta cells. PMID: 23828564
    12. Bim is a direct target of FoxO3a in Abeta-treated neurons. PMID: 23661003
    13. These results suggest that in sympathetic neurons, MEK-ERK signalling negatively regulates bim expression via the 3' UTR and that this regulation is likely to be at the level of transcription. PMID: 21762482
    14. Together with our previous finding that Bim(EL) is phosphorylated and activated by p38, these results demonstrate that p38 induces apoptosis by regulating Bim(EL) at both the transcriptional and post-translational levels. PMID: 18465250
    15. a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance. PMID: 21478148
    16. results indicate that increases in c-Fos following extracellular signal-regulated kinase activation are critical for BimEL upregulation and apoptosis PMID: 21439021
    17. Bim gene expression was transactivated by Egr-1 (early growth response 1) which uncovered a pathway that induces neuronal apoptosis. PMID: 21451041
    18. The amount of BimEL was elevated by its increased expression and decreased degradation, leading to apoptosis. PMID: 20857401
    19. has an anti-apoptotic function PMID: 11968853
    20. neurons are protected from the proapoptotic effects of Bim by Nerve Growth Factor both by acute phosphorylation and the longer term repression of expression PMID: 12388545
    21. results show that JNKs regulate the proapoptotic activity of BIM(EL) during trophic factor deprivation , both transcriptionally and posttranslationally PMID: 12818176
    22. Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection. PMID: 14667574
    23. The JNK signaling pathway is involved in ischemia-induced neuronal apoptosis partly by stimulation of Bax translocation to the mitochondria, in which BimL may be regulated by JNK as a downstream substrate for apoptotic signal transmission to Bax. PMID: 15356200
    24. overexpression of rat JNK inhibitory kinase in neuronal cells up-regulated the expression of BimEL PMID: 16092929
    25. Rac acts downstream of integrins and growth factors to promote neuronal survival by repressing c-Jun/Bim-mediated mitochondrial apoptosis. PMID: 16092944
    26. Induction of Bim in NGF-deprived cells requires expression and activity of cyclin-dependent kinase 4 and consequent de-repression of E2 promoter. PMID: 16162916
    27. Ser(87) of Bim(EL) is an important regulatory site that is targeted by Akt to attenuate the pro-apoptotic function of Bim(EL), thereby promoting cell survival PMID: 16282323
    28. Bim degradation by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons PMID: 16431916
    29. p38 induces apoptosis by phosphorylating Bim(EL) on Ser-65, which may be a common regulatory point for cell death induced by both JNK and p38 pathways PMID: 16818494
    30. Taken together, our data suggest that the activation of the JNK/c-Jun/BimEL signalling pathway plays a crucial role in lovastatin-induced neuroblast apoptosis. PMID: 17251057
    31. Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways PMID: 17702754
    32. BIM and tBID follow different strategies to trigger BAX-driven mitochondrial outer membrane permeabilization with strong potency PMID: 18195012
    33. Data show that glucagon-like peptide-1 suppresses Bim induction promoted by nerve growth factor deprivation, and suggest that GLP-1 may protect neurons, at least in part, by suppressing Bim induction. PMID: 18351462

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  • 亚细胞定位：
    Membrane; Peripheral membrane protein. Mitochondrion.
  • 蛋白家族：
    Bcl-2 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: rno:64547

    STRING: 10116.ENSRNOP00000039006

    UniGene: Rn.82709