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  4. Recombinant Rat Bcl-2-binding component 3 (Bbc3)

Recombinant Rat Bcl-2-binding component 3 (Bbc3)

  • 货号：
    CSB-YP802262RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP802262RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP802262RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP802262RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP802262RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Bbc3; PumaBcl-2-binding component 3; p53 up-regulated modulator of apoptosis
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-193
  • 氨基酸序列
    MARARQEGSS PEPVEGLARD SPRPFPLGRL MPSAVSCGLC EPGLPAAPAA PALLPAAYLC APTAPPAVTA ALGGPRWPGG HRSRPRGPRP DGPQPSLSPA QQHLESPVPS APEALAGGPT QAAPGVRVEE EEWAREIGAQ LRRMADDLNA QYERRRQEEQ HRHRPSPWRV MYNLFMGLLP LPRDPGAPEM EPN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Essential for ER stress-induced cell death.
  • 基因功能参考文献：
    1. These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets. PMID: 27117005
    2. Reduction of p53 upregulated modulator of apoptosis (PUMA) expression mediates the endogenous cardioprotective mechanisms of postconditioning by disrupting mitochondrial apoptotic pathway. PMID: 26043893
    3. we identified a novel AP1-binding site on rat puma gene which is necessary for direct binding of c-Jun with Puma promoter PMID: 25891762
    4. over-expression of PUMA correlates with cauda equina compression caused apoptosis of spinal cord cells PMID: 23658678
    5. An in vivo model of aorta-caval shunt and aortic banding showed increased PUMA protein expression in the aorta. PMID: 22021910
    6. Data show that transcriptional activation of PUMA is regulated by nuclear factor-kappaB and endoplasmic reticulum stress. PMID: 20421300
    7. Our study thus establishes Puma as an essential mediator of cardiomyocyte death upon I/R injury and offers a novel therapeutic target to limit cell loss in ischemic heart disease. PMID: 16399862
    8. These results imply a potential role for PUMA in delayed neuronal death after transient global cerebral ischemia PMID: 19095966

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Bcl-2 family
  • 数据库链接：

    KEGG: rno:317673

    STRING: 10116.ENSRNOP00000064216

    UniGene: Rn.25176