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  4. Recombinant Rat Aryl hydrocarbon receptor nuclear translocator (Arnt)

Recombinant Rat Aryl hydrocarbon receptor nuclear translocator (Arnt)

  • 货号：
    CSB-YP002121RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002121RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002121RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002121RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002121RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ArntAryl hydrocarbon receptor nuclear translocator; ARNT protein; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-800
  • 氨基酸序列
    AATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD DEGEVNSKFL RCDDEQMCND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNICQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR AKNREWLWMR TSSFTFQNPY SDEMSIFICT NTNVKNSSQE PRPTLSNTIQ RSQLGPTTNL SLEMGTGVLA SRQQQQQQQQ QQQQQQQQTE LDMVPGRDGL ASYSHSQVSV QPVATAGSEH SKPLEKSEGL FVQDRDPRFS EIYPNISADQ SKGLSSSTVP ATQQLFSQGS SFPPNPRPAE NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNLTQGSAPT WTSSTRPGFS AQLPTQATAK TRSSQFGVNN FQTSSSFSAM SLPGAPTASP STAAYPTLPN RGSNFPPETG QTTGQFQTRT AEGVGVWPQW QGQQPHHRSS SNEQHVQPTS AQPSSQPEVF QEMLSMLGDQ SNTYNNEEFP DLTMFPPFSE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
  • 基因功能参考文献：
    1. Data show that higher hypoxia inducible factors HIF-1alpha and HIF-1beta transcriptional activity augments lactate production in Sertoli cells. PMID: 27750035
    2. Loss of suppression on HIF-1beta by miR-103/107 may contribute to excess proliferation of pulmonary arterial smooth muscle cells and vascular remodeling in hypoxic pulmonary hypertension PMID: 26827991
    3. This study indicated that miR-107 was up-regulated in hypoxia to prevent endothelial progenitor cells differentiation via its target HIF-1beta. [HIF-1beta] PMID: 22792280
    4. Aryl hydrocarbon receptor activation may lead to downregulation of Wnt/beta-catenin signaling. PMID: 21602191
    5. The hypoxia-induced elevation in apelin expression is most likely mediated by HIF, since HIF-activated apelin transcriptional activity is dependent on an intact, putative HIF binding site in the rat apelin promoter. PMID: 18367654
    6. beta-cells with reduced ARNT/HIF-1beta expression levels exhibit a 31% reduction in glycolytic flux without significant changes in glucose oxidation or the ATP:ADP ratio PMID: 21059654
    7. experiments revealed a complex distribution of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator mRNAs and proteins in rat and human testis PMID: 12586752
    8. Identification of novel splice variants of ARNT. PMID: 12684048
    9. Data show that estradiol significantly increased the expression of aryl-hydrocarbon receptor (AhR) nuclear translocator 2 (Arnt2) mRNA in the hypothalamus, but induced no significant changes in the expression of AhR and Arnt1 mRNAs. PMID: 12859947
    10. bmal1 expression peaked at the the very late phase of the night, but the daily pattern of expression was arrhythmic or phase advanced in TGR rats. PMID: 17915197
    11. ARNT expresses K(ATP) channel and by so doing regulates glucose-dependent insulin secretion. PMID: 19141293

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: rno:25242

    STRING: 10116.ENSRNOP00000060764

    UniGene: Rn.10520