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  4. Recombinant Rat Alpha-2-HS-glycoprotein (Ahsg)

Recombinant Rat Alpha-2-HS-glycoprotein (Ahsg)

  • 货号：
    CSB-YP001485RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001485RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001485RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001485RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001485RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ahsg
  • Uniprot No.：
  • 别名：
    Ahsg; FetuaAlpha-2-HS-glycoprotein; 59 kDa bone sialic acid-containing protein; BSP; Fetuin-A; Glycoprotein PP63
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-352
  • 氨基酸序列
    AP QGAGLGFREL ACDDPETEHV ALIAVDYLNK HLLQGFRQIL NQIDKVKVWS RRPFGEVYEL EIDTLETTCH ALDPTPLANC SVRQQAEHAV EGDCDFHILK QDGQFRVLHA QCHSTPDSAE DVRKFCPRCP ILIRFNDTNV VHTVKTALAA FNAQNNGTYF KLVEISRAQN VPFPVSTLVE FVIAATDCTG QEVTDPAKCN LLAEKQYGFC KATLIHRLGG EEVSVACKLF QTQPQPANAN PAGPAPTVGQ AAPVAPPAGP PESVVVGPVA VPLGLPDHRT HHDLRHAFSP VASVESASGE VLHSPKVGQP GDAGAAGPVA PLCPGRVRYF KI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
  • 基因功能参考文献：
    1. Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis. PMID: 26828753
    2. The protective effects of pioglitazone on lipotoxicity in beta cells may involve the inhibition of the activation of the Fetuin A and TLR4 signaling pathway. PMID: 25986658
    3. Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls. PMID: 24994603
    4. We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis. PMID: 23710462
    5. Fetuin-A was found in cortex, white matter, subplate, hippocampus, subventricular zone, & ependymal cells which supports a global role for brain function. It decreased with age. PMID: 23109215
    6. Tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under parathyroid hormone-loaded condition. PMID: 23344571
    7. This protein may prevent glucose toxicity in cardiomyocates in the presence of insulin. PMID: 12203945

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Fetuin family
  • 组织特异性：
    Synthesized in liver and secreted by the hepatocytes in the blood.
  • 数据库链接：

    KEGG: rno:25373

    UniGene: Rn.32083